Filaggrin loss-of-function variants are associated with atopic comorbidity in pediatric inflammatory bowel disease

J. Van Limbergen, R. K. Russell, E. R. Nimmo, Y. Zhao, H. Liao, H. E. Drummond, G. Davies, P. M. Gillett, P. McGrogan, W. M. Bisset, G. Mahdi, D. C. Wilson, S. J. Brown, W. H. I. McLean, J. Satsangi

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    Abstract

    Background: Pediatric inflammatory bowel disease (IBD) has a high prevalence of coexistent atopy. Filaggrin (FLG) loss-of-function variants (null-alleles) are associated with eczema and asthma in association with eczema. The aim was to assess the contribution of FLG null-alleles to pediatric IBD susceptibility and to coexistent atopy (eczema, asthma, allergic rhinitis, or food allergy).

    Methods: FLG variants (R501X and 2282del4) were genotyped in 403 children with IBD, 683 parents, and 996 population controls.

    Results: In all, 11% of IBD patients carried at least I FLG null-allele compared to 11% of population controls (P > 0.4). Carriage of I or more null-alleles in patients with atopy (present in 52% of IBD patients) differed from IBD patients without atopy (14% versus 6%, P = 0.01; odds ratio [OR] 2.4, 95% confidence interval [CI] 1.2-5.1). The effect of FLG null-alleles was strongest for eczema (19% versus 7%, P = 0.0003; OR 3.3, 95% CI 1.7-6.6) and food allergy (28% versus 8%, P = 0.0001; OR 4.5, 95% CI 2.0-10.0). The presence of more than 1 atopic disease tended to increase the associated OR: eczema + asthma (23% versus 7%, P = 0.001; OR 3.9, 95% CI 1.6-9.1), eczema + asthma + allergic rhinitis (29% versus 7%, P = 0.0006; OR 5.4, 95% CI 1.9-15.4) and eczema + asthma + allergic rhinitis + food allergy (45% versus 6%, P < 10(-4); OR 12.2, 95% CI 3.2-46.3). Logistic regression analysis of IBD cases confirmed the association of carriage of an FLG null-allele with atopy (P = 0.01; OR 2.4, 95% CI 1.2-5.1) and co-occurrence of different forms of atopy (P = 0.003; OR 3.5, 95% CI 1.5-8.1).

    Conclusions: Filaggrin null-alleles have no effect on IBD susceptibility but contribute to coexistent eczema and food allergy.

    Original languageEnglish
    Pages (from-to)1492-1498
    Number of pages7
    JournalInflammatory Bowel Diseases
    Volume15
    Issue number10
    DOIs
    Publication statusPublished - Oct 2009

    Keywords

    • Filaggrin
    • Pediatrics
    • Inflammatory bowel disease
    • Asthma
    • Eczema
    • Onset Crohns disease
    • Function mutations
    • Confer susceptibility
    • Ichthyosis vulgaris
    • Null mutations
    • Phenotypic characters
    • Rheumatoid arthritis
    • Ulcerative colitis
    • Risk factors
    • Dermatitis

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