Filaggrin null alleles are not associated with psoriasis

Yiwei Zhao, Ana Terron-Kwiatkowski, Haihui Liao, Simon P. Lee, Michael H. Allen, Peter R. Hull, Linda E. Campbell, Richard C. Trembath, Francesca Capon, Christopher E. M. Griffiths, David Burden, Ross McManus, Rosalind Hughes, Brian Kirby, Sarah F. Rogers, Oliver Fitzgerald, David Kane, Jonathan N. W. N. Barker, Colin N. A. Palmer, Alan D. IrvineW. H. Irwin McLean

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    29 Citations (Scopus)

    Abstract

    Psoriasis is a common skin disease with an etiology consistent with a multifactorial trait. Several psoriasis susceptibility loci are known, a number of which are also implicated in a predisposition to atopic dermatitis (AD), including the epidermal differentiation complex on chromosome 1q21. It has recently been shown in several replicate studies that prevalent null alleles for the filaggrin gene (FLG) on 1q21 are an important genetic factor in AD. Here, we examined the role of these FLG variants in psoriasis using case:control association studies comparing Irish and UK psoriasis cohorts (combined n=691) to ethnically matched populations (combined n=2117). No association was present for the two common European FLG mutations R501X and 2282del4 (combined x² P=0.989). In addition, the 3' end of the FLG open-reading frame was sequenced in a number of patients with differing types of psoriasis (plaque, guttate, palmoplantar, and late-onset), which excluded the possibility of a gain-of-function frameshift mutation such as those found in loricrin or certain keratin genes. These data suggest that FLG mutations are unlikely to be involved in genetic susceptibility to psoriasis and implies that there may be within-locus heterogeneity in chromosomal regions involved in both AD and psoriasis.

    Original languageEnglish
    Pages (from-to)1878-1882
    Number of pages5
    JournalJournal of Investigative Dermatology
    Volume127
    Issue number8
    DOIs
    Publication statusPublished - Aug 2007

    Keywords

    • Adult
    • Dermatitis, Atopic
    • Genetic Predisposition to Disease
    • Humans
    • Intermediate Filament Proteins
    • Psoriasis

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  • Cite this

    Zhao, Y., Terron-Kwiatkowski, A., Liao, H., Lee, S. P., Allen, M. H., Hull, P. R., Campbell, L. E., Trembath, R. C., Capon, F., Griffiths, C. E. M., Burden, D., McManus, R., Hughes, R., Kirby, B., Rogers, S. F., Fitzgerald, O., Kane, D., Barker, J. N. W. N., Palmer, C. N. A., ... McLean, W. H. I. (2007). Filaggrin null alleles are not associated with psoriasis. Journal of Investigative Dermatology, 127(8), 1878-1882. https://doi.org/10.1038/sj.jid.5700817