Filaggrin's fuller figure: a glimpse into the genetic architecture of atopic dermatitis

Aileen Sandilands; Frances J. D. Smith; Alan D. Irvine; W. H. Irwin McLean

doi:10.1038/sj.jid.5700876

Filaggrin's fuller figure: a glimpse into the genetic architecture of atopic dermatitis

Aileen Sandilands, Frances J. D. Smith, Alan D. Irvine, W. H. Irwin McLean

Research output: Contribution to journal › Article › peer-review

110 Citations (Scopus)

Abstract

Prevalent mutations in the FLG gene underlie the common skin disorder ichthyosis vulgaris and are significant risk factors for atopic dermatitis (eczema). The recent publication of a strategy to sequence this difficult gene identifies a spectrum of both prevalent and rare mutations that collectively have a significant impact on susceptibility to atopic disease.

Original language	English
Pages (from-to)	1282-1284
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	127
Issue number	6
DOIs	https://doi.org/10.1038/sj.jid.5700876
Publication status	Published - Jun 2007

Keywords

Dermatitis, Atopic
Genetic Predisposition to Disease
Humans
Intermediate Filament Proteins
Prevalence
Risk Factors

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10.1038/sj.jid.5700876

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title = "Filaggrin's fuller figure: a glimpse into the genetic architecture of atopic dermatitis",

abstract = "Prevalent mutations in the FLG gene underlie the common skin disorder ichthyosis vulgaris and are significant risk factors for atopic dermatitis (eczema). The recent publication of a strategy to sequence this difficult gene identifies a spectrum of both prevalent and rare mutations that collectively have a significant impact on susceptibility to atopic disease.",

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KW - Genetic Predisposition to Disease

KW - Humans

KW - Intermediate Filament Proteins

KW - Prevalence

KW - Risk Factors

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Filaggrin's fuller figure: a glimpse into the genetic architecture of atopic dermatitis

Abstract

Keywords

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