Filaggrin's fuller figure: a glimpse into the genetic architecture of atopic dermatitis

Aileen Sandilands, Frances J. D. Smith, Alan D. Irvine, W. H. Irwin McLean

    Research output: Contribution to journalArticlepeer-review

    98 Citations (Scopus)

    Abstract

    Prevalent mutations in the FLG gene underlie the common skin disorder ichthyosis vulgaris and are significant risk factors for atopic dermatitis (eczema). The recent publication of a strategy to sequence this difficult gene identifies a spectrum of both prevalent and rare mutations that collectively have a significant impact on susceptibility to atopic disease.
    Original languageEnglish
    Pages (from-to)1282-1284
    Number of pages3
    JournalJournal of Investigative Dermatology
    Volume127
    Issue number6
    DOIs
    Publication statusPublished - Jun 2007

    Keywords

    • Dermatitis, Atopic
    • Genetic Predisposition to Disease
    • Humans
    • Intermediate Filament Proteins
    • Prevalence
    • Risk Factors

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