Finding the middle ground: how kinetochores power chromosome congression

Geert J. P. L. Kops; Adrian T. Saurin; Patrick Meraldi

doi:10.1007/s00018-010-0321-y

Finding the middle ground: how kinetochores power chromosome congression

Geert J. P. L. Kops, Adrian T. Saurin, Patrick Meraldi

Research output: Contribution to journal › Review article › peer-review

46 Citations (Scopus)

Abstract

Genomic stability requires error-free chromosome segregation during mitosis. Chromosome congression to the spindle equator precedes chromosome segregation in anaphase and is a hallmark of metazoan mitosis. Here we review the current knowledge and concepts on the processes that underlie chromosome congression, including initial attachment to spindle microtubules, biorientation, and movements, from the perspective of the kinetochore.

Original language	English
Pages (from-to)	2145-2161
Number of pages	17
Journal	Cellular and Molecular Life Sciences
Volume	67
Issue number	13
DOIs	https://doi.org/10.1007/s00018-010-0321-y
Publication status	Published - Jul 2010

Keywords

SPINDLE ASSEMBLY CHECKPOINT
MITOTIC SPINDLE
SOMATIC-CELLS
Kinetochore
KINESIN-RELATED PROTEIN
Chromosome
AURORA-B
Metaphase
CENP-E
Microtubule
SMALL-MOLECULE INHIBITOR
METAPHASE PLATE
Spindle
Mitosis
NEWT LUNG-CELLS
POLEWARD MICROTUBULE FLUX
Congression

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@article{c1e653dc156943169299319cadcd16ae,

title = "Finding the middle ground: how kinetochores power chromosome congression",

abstract = "Genomic stability requires error-free chromosome segregation during mitosis. Chromosome congression to the spindle equator precedes chromosome segregation in anaphase and is a hallmark of metazoan mitosis. Here we review the current knowledge and concepts on the processes that underlie chromosome congression, including initial attachment to spindle microtubules, biorientation, and movements, from the perspective of the kinetochore.",

keywords = "SPINDLE ASSEMBLY CHECKPOINT, MITOTIC SPINDLE, SOMATIC-CELLS, Kinetochore, KINESIN-RELATED PROTEIN, Chromosome, AURORA-B, Metaphase, CENP-E, Microtubule, SMALL-MOLECULE INHIBITOR, METAPHASE PLATE, Spindle, Mitosis, NEWT LUNG-CELLS, POLEWARD MICROTUBULE FLUX, Congression",

author = "Kops, {Geert J. P. L.} and Saurin, {Adrian T.} and Patrick Meraldi",

year = "2010",

month = jul,

doi = "10.1007/s00018-010-0321-y",

language = "English",

volume = "67",

pages = "2145--2161",

journal = "Cellular and Molecular Life Sciences",

issn = "1420-682X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "13",

}

TY - JOUR

T1 - Finding the middle ground: how kinetochores power chromosome congression

AU - Kops, Geert J. P. L.

AU - Saurin, Adrian T.

AU - Meraldi, Patrick

PY - 2010/7

Y1 - 2010/7

N2 - Genomic stability requires error-free chromosome segregation during mitosis. Chromosome congression to the spindle equator precedes chromosome segregation in anaphase and is a hallmark of metazoan mitosis. Here we review the current knowledge and concepts on the processes that underlie chromosome congression, including initial attachment to spindle microtubules, biorientation, and movements, from the perspective of the kinetochore.

AB - Genomic stability requires error-free chromosome segregation during mitosis. Chromosome congression to the spindle equator precedes chromosome segregation in anaphase and is a hallmark of metazoan mitosis. Here we review the current knowledge and concepts on the processes that underlie chromosome congression, including initial attachment to spindle microtubules, biorientation, and movements, from the perspective of the kinetochore.

KW - SPINDLE ASSEMBLY CHECKPOINT

KW - MITOTIC SPINDLE

KW - SOMATIC-CELLS

KW - Kinetochore

KW - KINESIN-RELATED PROTEIN

KW - Chromosome

KW - AURORA-B

KW - Metaphase

KW - CENP-E

KW - Microtubule

KW - SMALL-MOLECULE INHIBITOR

KW - METAPHASE PLATE

KW - Spindle

KW - Mitosis

KW - NEWT LUNG-CELLS

KW - POLEWARD MICROTUBULE FLUX

KW - Congression

U2 - 10.1007/s00018-010-0321-y

DO - 10.1007/s00018-010-0321-y

M3 - Review article

SN - 1420-682X

VL - 67

SP - 2145

EP - 2161

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

IS - 13

ER -

Finding the middle ground: how kinetochores power chromosome congression

Abstract

Keywords

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