Finding the middle ground: how kinetochores power chromosome congression

Geert J. P. L. Kops, Adrian T. Saurin, Patrick Meraldi

    Research output: Contribution to journalReview article

    40 Citations (Scopus)

    Abstract

    Genomic stability requires error-free chromosome segregation during mitosis. Chromosome congression to the spindle equator precedes chromosome segregation in anaphase and is a hallmark of metazoan mitosis. Here we review the current knowledge and concepts on the processes that underlie chromosome congression, including initial attachment to spindle microtubules, biorientation, and movements, from the perspective of the kinetochore.

    Original languageEnglish
    Pages (from-to)2145-2161
    Number of pages17
    JournalCellular and Molecular Life Sciences
    Volume67
    Issue number13
    DOIs
    Publication statusPublished - Jul 2010

    Keywords

    • SPINDLE ASSEMBLY CHECKPOINT
    • MITOTIC SPINDLE
    • SOMATIC-CELLS
    • Kinetochore
    • KINESIN-RELATED PROTEIN
    • Chromosome
    • AURORA-B
    • Metaphase
    • CENP-E
    • Microtubule
    • SMALL-MOLECULE INHIBITOR
    • METAPHASE PLATE
    • Spindle
    • Mitosis
    • NEWT LUNG-CELLS
    • POLEWARD MICROTUBULE FLUX
    • Congression

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