First synthesis of argadin: a nanomolar inhibitor of family-18 chitinases

Keyphrases

• Family 18 chitinase 100%
• First Synthesis 100%
• Diastereoisomers 100%
• Germany 50%
• High-resolution 50%
• Resin 50%
• Rapid Access 50%
• Amino 50%
• Side Chain 50%
• Histidine 50%
• Natural Products 50%
• Efficient Access 50%
• Solid Phase 50%
• X-ray Crystal Structure 50%
• Aspergillus Fumigatus 50%
• Homoserine 50%
• Representative Family 50%
• Cyclic Peptide 50%
• 2-pyrrolidone 50%
• Peptide Natural Products 50%
• Co. KGaA 50%
• Protecting Group Strategy 50%
• Oxidative Cyclization 50%
• Pyrrolidinone 50%

Chemistry

• Natural Product 100%
• Crystal Structure 50%
• Protecting Groups 50%
• Cyclic Peptide 50%
• Oxidative Cyclization 50%
• Inhibition Constant (Ki) 50%
• Histidine 50%
• Homoserine 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Natural Product 100%
• Chitinase 100%
• Histidine 50%
• Aspergillus fumigatus 50%
• Homoserine 50%
• Cyclopeptide 50%
• 2 Pyrrolidinone 50%