Fluorohydroxyproline derivatives useful in the preparation of proteolysis targeted chimeras

Alessio Ciulli; Andrea Testa

Fluorohydroxyproline derivatives useful in the preparation of proteolysis targeted chimeras

Alessio Ciulli (Inventor), Andrea Testa (Inventor)

Biological Chemistry and Drug Discovery

Research output: Patent

Abstract

There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, and to their utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for their preparation thereof, and use in medicine. There is particularly provided novel small molecule E3 ubiquitin ligase protein binding inhibitorcompounds based on a fluorohydroxyproline scaffold, to their utility as ligands in synthesizing novel PROTACs, and to synthetic methods therefor.

Original language	English
Patent number	WO/2018/051107
IPC	C07D 417/12 2006.1,C07D 417/14 2006.1,C07D 495/14 2006.1,A61K 31/427 2006.1,A61K 31/551 2006.1,A61P 35/00 2006.1,A61P 29/00 2006.1
Priority date	14/09/16
Filing date	14/09/17
Publication status	Published - 22 Mar 2018

Cite this

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title = "Fluorohydroxyproline derivatives useful in the preparation of proteolysis targeted chimeras",

abstract = "There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, and to their utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for their preparation thereof, and use in medicine. There is particularly provided novel small molecule E3 ubiquitin ligase protein binding inhibitorcompounds based on a fluorohydroxyproline scaffold, to their utility as ligands in synthesizing novel PROTACs, and to synthetic methods therefor.",

author = "Alessio Ciulli and Andrea Testa",

year = "2018",

month = mar,

day = "22",

language = "English",

type = "Patent",

note = "WO/2018/051107; C07D 417/12 2006.1,C07D 417/14 2006.1,C07D 495/14 2006.1,A61K 31/427 2006.1,A61K 31/551 2006.1,A61P 35/00 2006.1,A61P 29/00 2006.1",

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TY - PAT

T1 - Fluorohydroxyproline derivatives useful in the preparation of proteolysis targeted chimeras

AU - Ciulli, Alessio

AU - Testa, Andrea

PY - 2018/3/22

Y1 - 2018/3/22

N2 - There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, and to their utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for their preparation thereof, and use in medicine. There is particularly provided novel small molecule E3 ubiquitin ligase protein binding inhibitorcompounds based on a fluorohydroxyproline scaffold, to their utility as ligands in synthesizing novel PROTACs, and to synthetic methods therefor.

AB - There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, and to their utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for their preparation thereof, and use in medicine. There is particularly provided novel small molecule E3 ubiquitin ligase protein binding inhibitorcompounds based on a fluorohydroxyproline scaffold, to their utility as ligands in synthesizing novel PROTACs, and to synthetic methods therefor.

UR - https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2018051107

M3 - Patent

M1 - WO/2018/051107

Y2 - 2017/09/14

ER -

Fluorohydroxyproline derivatives useful in the preparation of proteolysis targeted chimeras

Abstract

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