Fluorometric optical sensor arrays for the detection of urinary bladder cancer specific volatile organic compounds in the urine of patients with frank hematuria: a prospective case-control study

TY - JOUR

T1 - Fluorometric optical sensor arrays for the detection of urinary bladder cancer specific volatile organic compounds in the urine of patients with frank hematuria

T2 - a prospective case-control study

AU - Zhu, Simian

AU - Huang, Zhihong

AU - Nabi, Ghulam

N1 - © 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - This study outlines a simple fluorometric optical sensor system for the sensitive, real time measurement of volatile organic compounds (VOCs) as biomarkers of urinary bladder cancer in patients presenting with frank hematuria and confirmed to have the disease on histopathology. Arrays of 24 sensor points based on fluorescence VOC sensitive materials were made. Urine samples of 38 consecutive patients with pathologically confirmed bladder tumours and 41 age and gender matched healthy controls were recruited and analysed using this sensor array. This system correctly classified 68 out of 79 urine samples with 84.21% sensitivity and 87.80% specificity; the system also achieved 66.67% sensitivity and 75.00% specificity for classification of high-grade and low-grade bladder cancer patients. This study showed promising results in the detection of urinary bladder cancer as well as to classify high grade versus low grade bladder cancers.

AB - This study outlines a simple fluorometric optical sensor system for the sensitive, real time measurement of volatile organic compounds (VOCs) as biomarkers of urinary bladder cancer in patients presenting with frank hematuria and confirmed to have the disease on histopathology. Arrays of 24 sensor points based on fluorescence VOC sensitive materials were made. Urine samples of 38 consecutive patients with pathologically confirmed bladder tumours and 41 age and gender matched healthy controls were recruited and analysed using this sensor array. This system correctly classified 68 out of 79 urine samples with 84.21% sensitivity and 87.80% specificity; the system also achieved 66.67% sensitivity and 75.00% specificity for classification of high-grade and low-grade bladder cancer patients. This study showed promising results in the detection of urinary bladder cancer as well as to classify high grade versus low grade bladder cancers.

U2 - 10.1364/BOE.380629

DO - 10.1364/BOE.380629

M3 - Article

C2 - 32133241

SN - 2156-7085

VL - 11

SP - 1175

EP - 1185

JO - Biomedical Optics Express

JF - Biomedical Optics Express

IS - 2

ER -