Fluorometric virus detection platform using quantum dots-gold nanocomposites optimizing the linker length variation

Fahmida Nasrin, Ankan Dutta Chowdhury, Kenshin Takemura, Ikko Kozaki, Hiroyuki Honda, Oluwasesan Adegoke, Enoch Y. Park (Lead / Corresponding author)

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In this study, a tunable biosensor using the localized surface plasmon resonance (LSPR), controlling thedistance betweenfluorescent CdZnSeS/ZnSeS quantum dots (QDs) and gold nanoparticles (AuNPs) hasbeen developed for the detection of virus. The distance between the AuNPs and QDs has been controlledby a linkage with a peptide chain of 18 amino acids. In the optimized condition, thefluorescent prop-erties of the QDs have been enhanced due to the surface plasmon effect of the adjacent AuNPs. Suc-cessive virus binding on the peptide chain induces steric hindrance on the LSPR behavior and thefluorescence of QDs has been quenched. After analyzing all the possible aspect of the CdZnSeS/ZnSeS QD-peptide-AuNP nanocomposites, we have detected different concentration of influenza virus in a linearrange of 10-14 to 10-9gmL-1with detection limit of 17.02 fg mL-1. On the basis of the obtained results,this proposed biosensor can be a good alternative for the detection of infectious viruses in the variousrange of sensing application.
Original languageEnglish
Pages (from-to)148-157
Number of pages10
JournalAnalytica Chimica Acta
Volume1109
Early online date22 Feb 2020
DOIs
Publication statusPublished - 1 May 2020

Keywords

  • Biosensor
  • Gold nanoparticle
  • Influenza virus
  • Localized surface plasmon resonance
  • Peptide
  • Quantum dots

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