Flying under the radar: CDH2 (N-cadherin), an important hub molecule in neurodevelopmental and neurodegenerative diseases

Zsófia I László, Zsolt Lele (Lead / Corresponding author)

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Abstract

CDH2 belongs to the classic cadherin family of Ca2+-dependent cell adhesion molecules with a meticulously described dual role in cell adhesion and β-catenin signaling. During CNS development, CDH2 is involved in a wide range of processes including maintenance of neuroepithelial integrity, neural tube closure (neurulation), confinement of radial glia progenitor cells (RGPCs) to the ventricular zone and maintaining their proliferation-differentiation balance, postmitotic neural precursor migration, axon guidance, synaptic development and maintenance. In the past few years, direct and indirect evidence linked CDH2 to various neurological diseases, and in this review, we summarize recent developments regarding CDH2 function and its involvement in pathological alterations of the CNS.

Original languageEnglish
Article number972059
Number of pages21
JournalFrontiers in Neuroscience
Volume16
DOIs
Publication statusPublished - 23 Sep 2022

Keywords

  • CDH2
  • N-cadherin
  • adhesion
  • brain development
  • neurodegenerative diseases
  • neurodevelopmental diseases

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