Folate and clefts of the lip and palate - A UK-based case-control study: Part 1: Dietary and supplemental folate

J. Little; M. Gilmour; P. A. Mossey; D. FitzPatrick; A. Cardy; J. Clayton-Smith; A. E. Fryer; ITS MAGIC Collaboration

doi:10.1597/06-150.1

Folate and clefts of the lip and palate - A UK-based case-control study: Part 1: Dietary and supplemental folate

J. Little, M. Gilmour, P. A. Mossey, D. FitzPatrick, A. Cardy, J. Clayton-Smith, A. E. Fryer, ITS MAGIC Collaboration

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Objectives: We sought to determine the associations between nonsyndromic cleft lip with or without cleft palate (CL +/- P) and cleft palate only (CP) and maternal intake of dietary folate and supplemental folic acid, in an area where the prevalence at birth of neural tube defects has been high and flour is not fortified with folic acid.

Methods: Interviews regarding periconceptional dietary intake and supplement use were completed with the mothers of 112 CL +/- P cases, 78 CP cases, and 248 unaffected infants. The data were analyzed by logistic regression methods.

Results: There was no overall association between CL +/- P and CP and either energy-adjusted total folate intake or supplemental folic acid use, irrespective of dosage.

Conclusion: Overall, higher intakes of total folate do not appear to prevent oral clefts in this population.

Original language	English
Pages (from-to)	420-427
Number of pages	8
Journal	Cleft Palate-Craniofacial Journal
Volume	45
Issue number	4
DOIs	https://doi.org/10.1597/06-150.1
Publication status	Published - 2008

Keywords

case-control study
folate
folic acid
cleft lip
cleft palate
epidemiology
NEURAL-TUBE DEFECTS
FOLIC-ACID SUPPLEMENTATION
NONSYNDROMIC ORAL CLEFTS
MATERNAL ALCOHOL-USE
OROFACIAL CLEFTS
BIRTH-DEFECTS
CONGENITAL-MALFORMATIONS
VITAMIN SUPPLEMENTATION
MULTIVITAMIN SUPPLEMENTATION
RISK

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Folate and clefts of the lip and palate - A UK-based case-control study: Part 1: Dietary and supplemental folate",

abstract = "Objectives: We sought to determine the associations between nonsyndromic cleft lip with or without cleft palate (CL +/- P) and cleft palate only (CP) and maternal intake of dietary folate and supplemental folic acid, in an area where the prevalence at birth of neural tube defects has been high and flour is not fortified with folic acid.Methods: Interviews regarding periconceptional dietary intake and supplement use were completed with the mothers of 112 CL +/- P cases, 78 CP cases, and 248 unaffected infants. The data were analyzed by logistic regression methods.Results: There was no overall association between CL +/- P and CP and either energy-adjusted total folate intake or supplemental folic acid use, irrespective of dosage.Conclusion: Overall, higher intakes of total folate do not appear to prevent oral clefts in this population.",

keywords = "case-control study, folate, folic acid, cleft lip, cleft palate, epidemiology, NEURAL-TUBE DEFECTS, FOLIC-ACID SUPPLEMENTATION, NONSYNDROMIC ORAL CLEFTS, MATERNAL ALCOHOL-USE, OROFACIAL CLEFTS, BIRTH-DEFECTS, CONGENITAL-MALFORMATIONS, VITAMIN SUPPLEMENTATION, MULTIVITAMIN SUPPLEMENTATION, RISK",

author = "J. Little and M. Gilmour and Mossey, {P. A.} and D. FitzPatrick and A. Cardy and J. Clayton-Smith and Fryer, {A. E.} and {ITS MAGIC Collaboration}",

year = "2008",

doi = "10.1597/06-150.1",

language = "English",

volume = "45",

pages = "420--427",

journal = "Cleft Palate-Craniofacial Journal",

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publisher = "SAGE Publications",

number = "4",

}

TY - JOUR

T1 - Folate and clefts of the lip and palate - A UK-based case-control study

T2 - Part 1: Dietary and supplemental folate

AU - Little, J.

AU - Gilmour, M.

AU - Mossey, P. A.

AU - FitzPatrick, D.

AU - Cardy, A.

AU - Clayton-Smith, J.

AU - Fryer, A. E.

AU - ITS MAGIC Collaboration

PY - 2008

Y1 - 2008

N2 - Objectives: We sought to determine the associations between nonsyndromic cleft lip with or without cleft palate (CL +/- P) and cleft palate only (CP) and maternal intake of dietary folate and supplemental folic acid, in an area where the prevalence at birth of neural tube defects has been high and flour is not fortified with folic acid.Methods: Interviews regarding periconceptional dietary intake and supplement use were completed with the mothers of 112 CL +/- P cases, 78 CP cases, and 248 unaffected infants. The data were analyzed by logistic regression methods.Results: There was no overall association between CL +/- P and CP and either energy-adjusted total folate intake or supplemental folic acid use, irrespective of dosage.Conclusion: Overall, higher intakes of total folate do not appear to prevent oral clefts in this population.

AB - Objectives: We sought to determine the associations between nonsyndromic cleft lip with or without cleft palate (CL +/- P) and cleft palate only (CP) and maternal intake of dietary folate and supplemental folic acid, in an area where the prevalence at birth of neural tube defects has been high and flour is not fortified with folic acid.Methods: Interviews regarding periconceptional dietary intake and supplement use were completed with the mothers of 112 CL +/- P cases, 78 CP cases, and 248 unaffected infants. The data were analyzed by logistic regression methods.Results: There was no overall association between CL +/- P and CP and either energy-adjusted total folate intake or supplemental folic acid use, irrespective of dosage.Conclusion: Overall, higher intakes of total folate do not appear to prevent oral clefts in this population.

KW - case-control study

KW - folate

KW - folic acid

KW - cleft lip

KW - cleft palate

KW - epidemiology

KW - NEURAL-TUBE DEFECTS

KW - FOLIC-ACID SUPPLEMENTATION

KW - NONSYNDROMIC ORAL CLEFTS

KW - MATERNAL ALCOHOL-USE

KW - OROFACIAL CLEFTS

KW - BIRTH-DEFECTS

KW - CONGENITAL-MALFORMATIONS

KW - VITAMIN SUPPLEMENTATION

KW - MULTIVITAMIN SUPPLEMENTATION

KW - RISK

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DO - 10.1597/06-150.1

M3 - Article

C2 - 18616361

SN - 1055-6656

VL - 45

SP - 420

EP - 427

JO - Cleft Palate-Craniofacial Journal

JF - Cleft Palate-Craniofacial Journal

IS - 4

ER -

Folate and clefts of the lip and palate - A UK-based case-control study: Part 1: Dietary and supplemental folate

Abstract

Keywords

UN SDGs

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