Folate and clefts of the lip and palate - A UK-based case-control study

Part 1: Dietary and supplemental folate

J. Little, M. Gilmour, P. A. Mossey, D. FitzPatrick, A. Cardy, J. Clayton-Smith, A. E. Fryer, ITS MAGIC Collaboration

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    Objectives: We sought to determine the associations between nonsyndromic cleft lip with or without cleft palate (CL +/- P) and cleft palate only (CP) and maternal intake of dietary folate and supplemental folic acid, in an area where the prevalence at birth of neural tube defects has been high and flour is not fortified with folic acid.

    Methods: Interviews regarding periconceptional dietary intake and supplement use were completed with the mothers of 112 CL +/- P cases, 78 CP cases, and 248 unaffected infants. The data were analyzed by logistic regression methods.

    Results: There was no overall association between CL +/- P and CP and either energy-adjusted total folate intake or supplemental folic acid use, irrespective of dosage.

    Conclusion: Overall, higher intakes of total folate do not appear to prevent oral clefts in this population.

    Original languageEnglish
    Pages (from-to)420-427
    Number of pages8
    JournalCleft Palate-Craniofacial Journal
    Volume45
    Issue number4
    DOIs
    Publication statusPublished - 2008

    Keywords

    • case-control study
    • folate
    • folic acid
    • cleft lip
    • cleft palate
    • epidemiology
    • NEURAL-TUBE DEFECTS
    • FOLIC-ACID SUPPLEMENTATION
    • NONSYNDROMIC ORAL CLEFTS
    • MATERNAL ALCOHOL-USE
    • OROFACIAL CLEFTS
    • BIRTH-DEFECTS
    • CONGENITAL-MALFORMATIONS
    • VITAMIN SUPPLEMENTATION
    • MULTIVITAMIN SUPPLEMENTATION
    • RISK

    Cite this

    Little, J., Gilmour, M., Mossey, P. A., FitzPatrick, D., Cardy, A., Clayton-Smith, J., ... ITS MAGIC Collaboration (2008). Folate and clefts of the lip and palate - A UK-based case-control study: Part 1: Dietary and supplemental folate. Cleft Palate-Craniofacial Journal, 45(4), 420-427. https://doi.org/10.1597/06-150.1
    Little, J. ; Gilmour, M. ; Mossey, P. A. ; FitzPatrick, D. ; Cardy, A. ; Clayton-Smith, J. ; Fryer, A. E. ; ITS MAGIC Collaboration. / Folate and clefts of the lip and palate - A UK-based case-control study : Part 1: Dietary and supplemental folate. In: Cleft Palate-Craniofacial Journal. 2008 ; Vol. 45, No. 4. pp. 420-427.
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    abstract = "Objectives: We sought to determine the associations between nonsyndromic cleft lip with or without cleft palate (CL +/- P) and cleft palate only (CP) and maternal intake of dietary folate and supplemental folic acid, in an area where the prevalence at birth of neural tube defects has been high and flour is not fortified with folic acid.Methods: Interviews regarding periconceptional dietary intake and supplement use were completed with the mothers of 112 CL +/- P cases, 78 CP cases, and 248 unaffected infants. The data were analyzed by logistic regression methods.Results: There was no overall association between CL +/- P and CP and either energy-adjusted total folate intake or supplemental folic acid use, irrespective of dosage.Conclusion: Overall, higher intakes of total folate do not appear to prevent oral clefts in this population.",
    keywords = "case-control study, folate, folic acid, cleft lip, cleft palate, epidemiology, NEURAL-TUBE DEFECTS, FOLIC-ACID SUPPLEMENTATION, NONSYNDROMIC ORAL CLEFTS, MATERNAL ALCOHOL-USE, OROFACIAL CLEFTS, BIRTH-DEFECTS, CONGENITAL-MALFORMATIONS, VITAMIN SUPPLEMENTATION, MULTIVITAMIN SUPPLEMENTATION, RISK",
    author = "J. Little and M. Gilmour and Mossey, {P. A.} and D. FitzPatrick and A. Cardy and J. Clayton-Smith and Fryer, {A. E.} and {ITS MAGIC Collaboration}",
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    Little, J, Gilmour, M, Mossey, PA, FitzPatrick, D, Cardy, A, Clayton-Smith, J, Fryer, AE & ITS MAGIC Collaboration 2008, 'Folate and clefts of the lip and palate - A UK-based case-control study: Part 1: Dietary and supplemental folate', Cleft Palate-Craniofacial Journal, vol. 45, no. 4, pp. 420-427. https://doi.org/10.1597/06-150.1

    Folate and clefts of the lip and palate - A UK-based case-control study : Part 1: Dietary and supplemental folate. / Little, J.; Gilmour, M.; Mossey, P. A.; FitzPatrick, D.; Cardy, A.; Clayton-Smith, J.; Fryer, A. E.; ITS MAGIC Collaboration.

    In: Cleft Palate-Craniofacial Journal, Vol. 45, No. 4, 2008, p. 420-427.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Folate and clefts of the lip and palate - A UK-based case-control study

    T2 - Part 1: Dietary and supplemental folate

    AU - Little, J.

    AU - Gilmour, M.

    AU - Mossey, P. A.

    AU - FitzPatrick, D.

    AU - Cardy, A.

    AU - Clayton-Smith, J.

    AU - Fryer, A. E.

    AU - ITS MAGIC Collaboration

    PY - 2008

    Y1 - 2008

    N2 - Objectives: We sought to determine the associations between nonsyndromic cleft lip with or without cleft palate (CL +/- P) and cleft palate only (CP) and maternal intake of dietary folate and supplemental folic acid, in an area where the prevalence at birth of neural tube defects has been high and flour is not fortified with folic acid.Methods: Interviews regarding periconceptional dietary intake and supplement use were completed with the mothers of 112 CL +/- P cases, 78 CP cases, and 248 unaffected infants. The data were analyzed by logistic regression methods.Results: There was no overall association between CL +/- P and CP and either energy-adjusted total folate intake or supplemental folic acid use, irrespective of dosage.Conclusion: Overall, higher intakes of total folate do not appear to prevent oral clefts in this population.

    AB - Objectives: We sought to determine the associations between nonsyndromic cleft lip with or without cleft palate (CL +/- P) and cleft palate only (CP) and maternal intake of dietary folate and supplemental folic acid, in an area where the prevalence at birth of neural tube defects has been high and flour is not fortified with folic acid.Methods: Interviews regarding periconceptional dietary intake and supplement use were completed with the mothers of 112 CL +/- P cases, 78 CP cases, and 248 unaffected infants. The data were analyzed by logistic regression methods.Results: There was no overall association between CL +/- P and CP and either energy-adjusted total folate intake or supplemental folic acid use, irrespective of dosage.Conclusion: Overall, higher intakes of total folate do not appear to prevent oral clefts in this population.

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    KW - NONSYNDROMIC ORAL CLEFTS

    KW - MATERNAL ALCOHOL-USE

    KW - OROFACIAL CLEFTS

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    KW - VITAMIN SUPPLEMENTATION

    KW - MULTIVITAMIN SUPPLEMENTATION

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    JO - Cleft Palate-Craniofacial Journal

    JF - Cleft Palate-Craniofacial Journal

    SN - 1055-6656

    IS - 4

    ER -