Folate Functionalized Boron Nitride Nanotubes and their Selective Uptake by Glioblastoma Multiforme Cells: Implications for their Use as Boron Carriers in Clinical Boron Neutron Capture Therapy

Gianni Ciofani, Vittoria Raffa, Arianna Menciassi, Alfred Cuschieri

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    115 Citations (Scopus)

    Abstract

    Boron neutron capture therapy (BNCT) is increasingly being used in the treatment of several aggressive cancers, including cerebral glioblastoma multiforme. The main requirement for this therapy is selective targeting of tumor cells by sufficient quantities of B-10 atoms required for their capture/irradiation with low-energy thermal neutrons. The low content of boron targeting species in glioblastoma multiforme accounts for the difficulty in selective targeting of this very malignant cerebral tumor by this radiation modality. In the present study, we have used for the first time boron nitride nanotubes as carriers of boron atoms to overcome this problem and enhance the selective targeting and ablative efficacy of BNCT for these tumors. Following their dispersion in aqueous solution by noncovalent coating with biocompatible poly-l-lysine solutions, boron nitride nanotubes were functionalized with a fluorescent probe (quantum dots) to enable their tracking and with folic acid as selective tumor targeting ligand. Initial in vitro studies have confirmed substantive and selective uptake of these nanovectors by glioblastoma multiforme cells, an observation which confirms their potential clinical application for BNCT therapy for these malignant cerebral tumors.

    Original languageEnglish
    Pages (from-to)113-121
    Number of pages9
    JournalNanoscale Research Letters
    Volume4
    Issue number2
    DOIs
    Publication statusPublished - Feb 2009

    Keywords

    • Boron nitride nanotubes
    • Folate
    • Glioblastoma multiforme
    • Boron neutron capture therapy
    • TARGETED DELIVERY
    • CARBON NANOTUBES
    • ELASTIC-MODULUS
    • IN-VITRO
    • CANCER
    • NANOPARTICLES
    • ACCUMULATION
    • RESISTANCE
    • RADIATION
    • PROSPECTS

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