TY - GEN
T1 - Four-dimensional optical coherence elastography (OCE) for assessing cutaneous leishmaniasis lesions and treatment response in murine model
AU - Zhang, Yilong
AU - Zhang, Tianyu
AU - Van Bocxlaer, Katrien
AU - Feng, Zhengshuyi
AU - Li, Chunhui
AU - Huang, Zhihong
N1 - Publisher Copyright:
© 2025 IEEE.
PY - 2025/9/15
Y1 - 2025/9/15
N2 - Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis, manifesting as skin lesions that can lead to scarring and may have lifelong impacts on well-being. Early and accurate assessment of lesion biomechanics could enhance diagnosis and therapeutic monitoring. In this study, we evaluate the feasibility of four-dimensional (4D) dynamic optical coherence elastography (OCE) for in vivo characterization of CL lesions in murine model. Four mice at distinct disease stages: healthy baseline, day 1 post-infection, developed lesion, and post-treatment, were scanned. Volumetric elasticity values were obtained by calculating local elastic wave velocities. Healthy skin exhibited uniform wave propagation with an average Young's modulus of 19±2 kPa, and a similar value was observed at day 1 post-infection (20±5 kPa). In contrast, developed lesions displayed markedly increased stiffness (511±238 kPa), which decreased following treatment (68±27 kPa). These findings demonstrate that 4D dynamic OCE can quantitatively and non-invasively detect biomechanical changes associated with CL progression and treatment response, supporting its potential as a diagnostic and monitoring tool in clinical settings.
AB - Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis, manifesting as skin lesions that can lead to scarring and may have lifelong impacts on well-being. Early and accurate assessment of lesion biomechanics could enhance diagnosis and therapeutic monitoring. In this study, we evaluate the feasibility of four-dimensional (4D) dynamic optical coherence elastography (OCE) for in vivo characterization of CL lesions in murine model. Four mice at distinct disease stages: healthy baseline, day 1 post-infection, developed lesion, and post-treatment, were scanned. Volumetric elasticity values were obtained by calculating local elastic wave velocities. Healthy skin exhibited uniform wave propagation with an average Young's modulus of 19±2 kPa, and a similar value was observed at day 1 post-infection (20±5 kPa). In contrast, developed lesions displayed markedly increased stiffness (511±238 kPa), which decreased following treatment (68±27 kPa). These findings demonstrate that 4D dynamic OCE can quantitatively and non-invasively detect biomechanical changes associated with CL progression and treatment response, supporting its potential as a diagnostic and monitoring tool in clinical settings.
KW - Biomechanical properties
KW - Cutaneous leishmaniasis (CL)
KW - four-dimensional (4D)
KW - Murine model
KW - optical coherence elastography (OCE)
UR - https://www.scopus.com/pages/publications/105021815416
U2 - 10.1109/IUS62464.2025.11201381
DO - 10.1109/IUS62464.2025.11201381
M3 - Conference contribution
AN - SCOPUS:105021815416
T3 - IEEE International Ultrasonics Symposium, IUS
BT - 2025 IEEE International Ultrasonics Symposium, IUS 2025
PB - IEEE Computer Society
CY - Utrecht
T2 - 2025 IEEE International Ultrasonics Symposium, IUS 2025
Y2 - 15 September 2025 through 18 September 2025
ER -