TY - GEN
T1 - Four-Dimensional Wave Propagation Measurements with Optical Coherence Elastography for Human Facial Acne Applications
AU - Feng, Zhengshuyi
AU - Zhang, Tianyu
AU - Liao, Jinpeng
AU - Zhang, Yilong
AU - Jiang, Weiyi
AU - Li, Chunhui
AU - Huang, Zhihong
N1 - Publisher Copyright:
© 2025 IEEE.
PY - 2025/9/15
Y1 - 2025/9/15
N2 - Acne is a prevalent skin condition, especially among adolescents, and current diagnostic methods such as biopsy are invasive and may cause patient discomfort. To address the need for a non-invasive, quantitative assessment, this study proposes the use of three-dimensional (3D) optical coherence elastography (OCE) to monitor the biomechanical properties of facial acne. Leveraging the combination of swept-source optical coherence tomography (SS-OCT) with high resolution and an external stimulation system to induce surface acoustic wave (SAW), the mean stiffness (Young's modulus) of facial acne was measured and monitored over time. Datasets from five participants were collected, including healthy skin (mean Young's modulus: 56.88 ± 13.30 kPa) and facial acne scanned on Day 1, Day 5, and Day 10, separately. Results demonstrated an example with a significant difference in stiffness between the facial acne region and surrounding skin, with facial acne areas showing a higher initial modulus (368.61 ± 75.06 kPa). For the ten facial acne datasets over the 10-day observation period, the normalized Young's modulus of acne lesions decreased to 46.24%, reflecting the healing process. Also, in this exemplary data, the propagation of SAW is shown in two-dimensional (2D) and 3D separately in different frames. This study highlights the potential of 3D OCE for non-invasive, quantitative evaluation of acne development, offering clinicians a valuable tool for diagnosis, monitoring, and treatment planning. Future works should focus on increasing the number of participants to enlarge the database.
AB - Acne is a prevalent skin condition, especially among adolescents, and current diagnostic methods such as biopsy are invasive and may cause patient discomfort. To address the need for a non-invasive, quantitative assessment, this study proposes the use of three-dimensional (3D) optical coherence elastography (OCE) to monitor the biomechanical properties of facial acne. Leveraging the combination of swept-source optical coherence tomography (SS-OCT) with high resolution and an external stimulation system to induce surface acoustic wave (SAW), the mean stiffness (Young's modulus) of facial acne was measured and monitored over time. Datasets from five participants were collected, including healthy skin (mean Young's modulus: 56.88 ± 13.30 kPa) and facial acne scanned on Day 1, Day 5, and Day 10, separately. Results demonstrated an example with a significant difference in stiffness between the facial acne region and surrounding skin, with facial acne areas showing a higher initial modulus (368.61 ± 75.06 kPa). For the ten facial acne datasets over the 10-day observation period, the normalized Young's modulus of acne lesions decreased to 46.24%, reflecting the healing process. Also, in this exemplary data, the propagation of SAW is shown in two-dimensional (2D) and 3D separately in different frames. This study highlights the potential of 3D OCE for non-invasive, quantitative evaluation of acne development, offering clinicians a valuable tool for diagnosis, monitoring, and treatment planning. Future works should focus on increasing the number of participants to enlarge the database.
KW - facial acne
KW - in vivo human skin
KW - optical coherence elastography (OCE)
KW - optical coherence tomography (OCT)
KW - surface acoustic wave (SAW)
KW - Young's Modulus
UR - https://www.scopus.com/pages/publications/105021822460
U2 - 10.1109/IUS62464.2025.11201584
DO - 10.1109/IUS62464.2025.11201584
M3 - Conference contribution
AN - SCOPUS:105021822460
T3 - IEEE International Ultrasonics Symposium, IUS
BT - 2025 IEEE International Ultrasonics Symposium, IUS 2025
PB - IEEE Computer Society
CY - Utrecht
T2 - 2025 IEEE International Ultrasonics Symposium, IUS 2025
Y2 - 15 September 2025 through 18 September 2025
ER -