Fragment-based drug discovery in academia: Experiences from a tuberculosis programme

T.J. Heikkila, S. Surade, H.L. Silvestre, M.V.B. Dias, A. Ciulli, K. Bromfield, D. Scott, N. Howard, S. Wen, A.H. Wei, D. Osborne, C. Abell, T.L. Blundell

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2 Citations (Scopus)

    Abstract

    The problems associated with neglected diseases are often compounded by increasing incidence of antibiotic resistance. Patient negligence and abuse of antibiotics has lead to explosive growth in cases of tuberculosis, with some M. tuberculosis strains becoming virtually untreatable. Structure-based drug development is viewed as cost-effective and time-consuming method for discovery and development of hits to lead compounds. In this review we will discuss the suitability of fragment-based methods for developing new chemotherapeutics against neglected diseases, providing examples from our tuberculosis programme.
    Original languageEnglish
    Title of host publicationFrom Molecules to Medicines
    Subtitle of host publicationStructure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism
    EditorsJoel L. Sussman, Paola Spadon
    PublisherSpringer Netherlands
    Pages21-36
    Number of pages16
    ISBN (Electronic)9789048123391
    ISBN (Print)9789048123384
    DOIs
    Publication statusPublished - 2009

    Publication series

    NameNATO Science for Peace and Security Series A: Chemistry and Biology
    ISSN (Print)1874-6489

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