The problems associated with neglected diseases are often compounded by increasing incidence of antibiotic resistance. Patient negligence and abuse of antibiotics has lead to explosive growth in cases of tuberculosis, with some M. tuberculosis strains becoming virtually untreatable. Structure-based drug development is viewed as cost-effective and time-consuming method for discovery and development of hits to lead compounds. In this review we will discuss the suitability of fragment-based methods for developing new chemotherapeutics against neglected diseases, providing examples from our tuberculosis programme.
|Title of host publication||From Molecules to Medicines|
|Subtitle of host publication||Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism|
|Editors||Joel L. Sussman, Paola Spadon|
|Number of pages||16|
|Publication status||Published - 2009|
|Name||NATO Science for Peace and Security Series A: Chemistry and Biology|