Fragment library design, synthesis and expansion: nurturing a synthesis and training platform

Peter C. Ray, Michael Kiczun, Margaret Huggett, Andrew Lim, Federica Prati, Ian H. Gilbert (Lead / Corresponding author), Paul G. Wyatt (Lead / Corresponding author)

Research output: Contribution to journalReview article

16 Citations (Scopus)
368 Downloads (Pure)

Abstract

The availability of suitable diverse fragment- and lead-oriented screening compounds is key for the identification of suitable chemical starting points for drug discovery programs. The physicochemical properties of molecules are crucial in determining the success of small molecules in clinical development, yet reports suggest that pharmaceutical and academic sectors often produce molecules with poor drug-like properties. We present a platform to design novel, high quality and diverse fragment- and lead-oriented libraries with appropriate physicochemical properties in a cost-efficient manner. This approach has the potential to assist the way libraries are constructed by significantly addressing the historical uneven exploration of chemical space for drug discovery. Additionally, this platform can teach undergraduates and graduates about compound library design.

Original languageEnglish
Pages (from-to)43-56
Number of pages14
JournalDrug Discovery Today
Volume22
Issue number1
Early online date26 Oct 2016
DOIs
Publication statusPublished - Jan 2017

Fingerprint Dive into the research topics of 'Fragment library design, synthesis and expansion: nurturing a synthesis and training platform'. Together they form a unique fingerprint.

  • Profiles

    No photo of Paul Wyatt

    Wyatt, Paul

    Person: Academic

    Cite this