Free radical pathology in chronic arterial disease

Jill J. F. Belch; Mridula Chopra; Stephen Hutchison; Ross Lorimer; Roger D. Sturrock; Charles D. Forbes; W. Ewan  Smith

doi:10.1016/0891-5849(89)90082-8

Free radical pathology in chronic arterial disease

Jill J. F. Belch, Mridula Chopra, Stephen Hutchison, Ross Lorimer, Roger D. Sturrock, Charles D. Forbes, W. Ewan Smith

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

The generation of toxic oxygen metabolites is more usually associated with inflammation. However, pathological free radical reactions can cause tissue damage by adversely affecting prostacyclin (PGI2) synthesis allowing initiation of coagulation. We have assessed changes in the red cell defence to toxic oxygen metabolite generation, viz measurement of glutathione concentration (GSH) and superoxide dismutase activity (SOD). GSH and SOD were measured in 20 patients with peripheral arterial disease, 22 patients with vasculitis, and 11 patients with angina, and compared to 17 matched controls. The 53 subjects with arterial disease had significantly lower SOD levels: in contrast GSH levels were significantly higher. Extracellularly plasma thiol levels (PSH) were low and caeruloplasmin (Cp) levels were high. We suggest that free radical pathology exists not only in inflammatory vascular disease but also in atherosclerosis.

Original language	English
Pages (from-to)	375-378
Number of pages	4
Journal	Free Radical Biology and Medicine
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/0891-5849(89)90082-8
Publication status	Published - 1989

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title = "Free radical pathology in chronic arterial disease",

abstract = "The generation of toxic oxygen metabolites is more usually associated with inflammation. However, pathological free radical reactions can cause tissue damage by adversely affecting prostacyclin (PGI2) synthesis allowing initiation of coagulation. We have assessed changes in the red cell defence to toxic oxygen metabolite generation, viz measurement of glutathione concentration (GSH) and superoxide dismutase activity (SOD). GSH and SOD were measured in 20 patients with peripheral arterial disease, 22 patients with vasculitis, and 11 patients with angina, and compared to 17 matched controls. The 53 subjects with arterial disease had significantly lower SOD levels: in contrast GSH levels were significantly higher. Extracellularly plasma thiol levels (PSH) were low and caeruloplasmin (Cp) levels were high. We suggest that free radical pathology exists not only in inflammatory vascular disease but also in atherosclerosis.",

author = "Belch, {Jill J. F.} and Mridula Chopra and Stephen Hutchison and Ross Lorimer and Sturrock, {Roger D.} and Forbes, {Charles D.} and Smith, {W. Ewan}",

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T1 - Free radical pathology in chronic arterial disease

AU - Belch, Jill J. F.

AU - Chopra, Mridula

AU - Hutchison, Stephen

AU - Lorimer, Ross

AU - Sturrock, Roger D.

AU - Forbes, Charles D.

AU - Smith, W. Ewan

PY - 1989

Y1 - 1989

N2 - The generation of toxic oxygen metabolites is more usually associated with inflammation. However, pathological free radical reactions can cause tissue damage by adversely affecting prostacyclin (PGI2) synthesis allowing initiation of coagulation. We have assessed changes in the red cell defence to toxic oxygen metabolite generation, viz measurement of glutathione concentration (GSH) and superoxide dismutase activity (SOD). GSH and SOD were measured in 20 patients with peripheral arterial disease, 22 patients with vasculitis, and 11 patients with angina, and compared to 17 matched controls. The 53 subjects with arterial disease had significantly lower SOD levels: in contrast GSH levels were significantly higher. Extracellularly plasma thiol levels (PSH) were low and caeruloplasmin (Cp) levels were high. We suggest that free radical pathology exists not only in inflammatory vascular disease but also in atherosclerosis.

AB - The generation of toxic oxygen metabolites is more usually associated with inflammation. However, pathological free radical reactions can cause tissue damage by adversely affecting prostacyclin (PGI2) synthesis allowing initiation of coagulation. We have assessed changes in the red cell defence to toxic oxygen metabolite generation, viz measurement of glutathione concentration (GSH) and superoxide dismutase activity (SOD). GSH and SOD were measured in 20 patients with peripheral arterial disease, 22 patients with vasculitis, and 11 patients with angina, and compared to 17 matched controls. The 53 subjects with arterial disease had significantly lower SOD levels: in contrast GSH levels were significantly higher. Extracellularly plasma thiol levels (PSH) were low and caeruloplasmin (Cp) levels were high. We suggest that free radical pathology exists not only in inflammatory vascular disease but also in atherosclerosis.

U2 - 10.1016/0891-5849(89)90082-8

DO - 10.1016/0891-5849(89)90082-8

M3 - Article

C2 - 2707621

SN - 0891-5849

VL - 6

SP - 375

EP - 378

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

IS - 4

ER -

Free radical pathology in chronic arterial disease

Abstract

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