Linked Articles This article is a Commentary on Thanawala VJ, Valdez DJ, Joshi R, Forkuo GS, Parra S, Knoll BJ, Bouvier M, Leff P and Bond RA (2015). Beta-blockers have differential effects on the murine asthma phenotype. Br J Pharmacol 172: 4833-4846. doi: 10.1111/bph.13253. The authors reply in Bond RA (2016). Differences in asthma study models and the effectiveness of β2-adrenoceptor ligands: response to Lipworth et al. Br J Pharmacol 173: 250-251. doi: 10.1111/bph.13334.