TY - JOUR
T1 - From snoRNA to miRNA
T2 - Dual function regulatory non-coding RNAs
AU - Scott, Michelle S.
AU - Ono, Motoharu
N1 - MEDLINE® is the source for the MeSH terms of this document.
PY - 2011/11/1
Y1 - 2011/11/1
N2 - Small nucleolar RNAs (snoRNAs) are an ancient class of small non-coding RNAs present in all eukaryotes and a subset of archaea that carry out a fundamental role in the modification and processing of ribosomal RNA. In recent years, however, a large proportion of snoRNAs have been found to be further processed into smaller molecules, some of which display different functionality. In parallel, several studies have uncovered extensive similarities between snoRNAs and other types of small non-coding RNAs, and in particular microRNAs. Here, we explore the extent of the relationship between these types of non-coding RNA and the possible underlying evolutionary forces that shaped this subset of the current non-coding RNA landscape.
AB - Small nucleolar RNAs (snoRNAs) are an ancient class of small non-coding RNAs present in all eukaryotes and a subset of archaea that carry out a fundamental role in the modification and processing of ribosomal RNA. In recent years, however, a large proportion of snoRNAs have been found to be further processed into smaller molecules, some of which display different functionality. In parallel, several studies have uncovered extensive similarities between snoRNAs and other types of small non-coding RNAs, and in particular microRNAs. Here, we explore the extent of the relationship between these types of non-coding RNA and the possible underlying evolutionary forces that shaped this subset of the current non-coding RNA landscape.
UR - http://www.scopus.com/inward/record.url?scp=80053574876&partnerID=8YFLogxK
U2 - 10.1016/j.biochi.2011.05.026
DO - 10.1016/j.biochi.2011.05.026
M3 - Article
C2 - 21664409
AN - SCOPUS:80053574876
SN - 0300-9084
VL - 93
SP - 1987
EP - 1992
JO - Biochimie
JF - Biochimie
IS - 11
ER -