From snoRNA to miRNA: Dual function regulatory non-coding RNAs

Michelle S. Scott, Motoharu Ono

    Research output: Contribution to journalArticle

    129 Citations (Scopus)

    Abstract

    Small nucleolar RNAs (snoRNAs) are an ancient class of small non-coding RNAs present in all eukaryotes and a subset of archaea that carry out a fundamental role in the modification and processing of ribosomal RNA. In recent years, however, a large proportion of snoRNAs have been found to be further processed into smaller molecules, some of which display different functionality. In parallel, several studies have uncovered extensive similarities between snoRNAs and other types of small non-coding RNAs, and in particular microRNAs. Here, we explore the extent of the relationship between these types of non-coding RNA and the possible underlying evolutionary forces that shaped this subset of the current non-coding RNA landscape.
    Original languageEnglish
    Pages (from-to)1987-1992
    Number of pages6
    JournalBiochimie
    Volume93
    Issue number11
    DOIs
    Publication statusPublished - 1 Nov 2011

      Fingerprint

    Cite this