Full skin quantitative optical coherence elastography achieved by combining vibration and surface acoustic wave methods

Chunhui Li; Guangying Guan; Zhihong Huang; Ruikang K. Wang; Ghulam Nabi

doi:10.1117/12.2075666

Full skin quantitative optical coherence elastography achieved by combining vibration and surface acoustic wave methods

Chunhui Li, Guangying Guan, Zhihong Huang, Ruikang K. Wang, Ghulam Nabi (Lead / Corresponding author)

Science and Engineering Office

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

10 Citations (Scopus)

Abstract

By combining with the phase sensitive optical coherence tomography (PhS-OCT), vibration and surface acoustic wave (SAW) methods have been reported to provide elastography of skin tissue respectively. However, neither of these two methods can provide the elastography in full skin depth in current systems. This paper presents a feasibility study on an optical coherence elastography method which combines both vibration and SAW in order to give the quantitative mechanical properties of skin tissue with full depth range, including epidermis, dermis and subcutaneous fat. Experiments are carried out on layered tissue mimicking phantoms and in vivo human forearm and palm skin. A ring actuator generates vibration while a line actuator were used to excited SAWs. A PhS-OCT system is employed to provide the ultrahigh sensitive measurement of the generated waves. The experimental results demonstrate that by the combination of vibration and SAW method the full skin bulk mechanical properties can be quantitatively measured and further the elastography can be obtained with a sensing depth from ∼0mm to ∼4mm. This method is promising to apply in clinics where the quantitative elasticity of localized skin diseases is needed to aid the diagnosis and treatment.

Original language	English
Title of host publication	Proceedings Volume 9322
Subtitle of host publication	Dynamics and Fluctuations in Biomedical Photonics XII
Editors	Valery V. Tuchin, Kirill V. Larin, Martin J. Leahy, Ruikang K. Wang
Publisher	SPIE-International Society for Optical Engineering
Number of pages	9
Volume	9322
ISBN (Electronic)	9781628414127
DOIs	https://doi.org/10.1117/12.2075666
Publication status	Published - 5 Mar 2015
Event	SPIE Photonics West 2015: Dynamics and Fluctuations in Biomedical Photonics XII - Moscone Center, San Francisco, United States Duration: 7 Feb 2015 → 8 Feb 2015 http://spie.org/conferences-and-exhibitions/past-conferences-and-exhibitions/photonics-west-2015 (Link to Conference details)

Publication series

Name
ISSN (Electronic)	1605-7422

Conference

Conference	SPIE Photonics West 2015
Country/Territory	United States
City	San Francisco
Period	7/02/15 → 8/02/15
Internet address	http://spie.org/conferences-and-exhibitions/past-conferences-and-exhibitions/photonics-west-2015 (Link to Conference details)

Keywords

Elastic properties
Elastography
Phase-sensitive optical coherence tomography (PhS-OCT)
Skin disease
Surface acoustic waves (SAWs)
Vibration

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Biomaterials
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/12.2075666

Cite this

Li, C., Guan, G., Huang, Z., Wang, R. K., & Nabi, G. (2015). Full skin quantitative optical coherence elastography achieved by combining vibration and surface acoustic wave methods. In V. V. Tuchin, K. V. Larin, M. J. Leahy, & R. K. Wang (Eds.), Proceedings Volume 9322: Dynamics and Fluctuations in Biomedical Photonics XII (Vol. 9322). Article 93220O SPIE-International Society for Optical Engineering. https://doi.org/10.1117/12.2075666

Li, Chunhui ; Guan, Guangying ; Huang, Zhihong et al. / Full skin quantitative optical coherence elastography achieved by combining vibration and surface acoustic wave methods. Proceedings Volume 9322: Dynamics and Fluctuations in Biomedical Photonics XII. editor / Valery V. Tuchin ; Kirill V. Larin ; Martin J. Leahy ; Ruikang K. Wang. Vol. 9322 SPIE-International Society for Optical Engineering, 2015.

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title = "Full skin quantitative optical coherence elastography achieved by combining vibration and surface acoustic wave methods",

abstract = "By combining with the phase sensitive optical coherence tomography (PhS-OCT), vibration and surface acoustic wave (SAW) methods have been reported to provide elastography of skin tissue respectively. However, neither of these two methods can provide the elastography in full skin depth in current systems. This paper presents a feasibility study on an optical coherence elastography method which combines both vibration and SAW in order to give the quantitative mechanical properties of skin tissue with full depth range, including epidermis, dermis and subcutaneous fat. Experiments are carried out on layered tissue mimicking phantoms and in vivo human forearm and palm skin. A ring actuator generates vibration while a line actuator were used to excited SAWs. A PhS-OCT system is employed to provide the ultrahigh sensitive measurement of the generated waves. The experimental results demonstrate that by the combination of vibration and SAW method the full skin bulk mechanical properties can be quantitatively measured and further the elastography can be obtained with a sensing depth from ∼0mm to ∼4mm. This method is promising to apply in clinics where the quantitative elasticity of localized skin diseases is needed to aid the diagnosis and treatment.",

keywords = "Elastic properties, Elastography, Phase-sensitive optical coherence tomography (PhS-OCT), Skin disease, Surface acoustic waves (SAWs), Vibration",

author = "Chunhui Li and Guangying Guan and Zhihong Huang and Wang, {Ruikang K.} and Ghulam Nabi",

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doi = "10.1117/12.2075666",

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note = "SPIE Photonics West 2015 : Dynamics and Fluctuations in Biomedical Photonics XII ; Conference date: 07-02-2015 Through 08-02-2015",

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Li, C, Guan, G, Huang, Z, Wang, RK & Nabi, G 2015, Full skin quantitative optical coherence elastography achieved by combining vibration and surface acoustic wave methods. in VV Tuchin, KV Larin, MJ Leahy & RK Wang (eds), Proceedings Volume 9322: Dynamics and Fluctuations in Biomedical Photonics XII. vol. 9322, 93220O, SPIE-International Society for Optical Engineering, SPIE Photonics West 2015, San Francisco, United States, 7/02/15. https://doi.org/10.1117/12.2075666

Full skin quantitative optical coherence elastography achieved by combining vibration and surface acoustic wave methods. / Li, Chunhui; Guan, Guangying; Huang, Zhihong et al.
Proceedings Volume 9322: Dynamics and Fluctuations in Biomedical Photonics XII. ed. / Valery V. Tuchin; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang. Vol. 9322 SPIE-International Society for Optical Engineering, 2015. 93220O.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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T1 - Full skin quantitative optical coherence elastography achieved by combining vibration and surface acoustic wave methods

AU - Li, Chunhui

AU - Guan, Guangying

AU - Huang, Zhihong

AU - Wang, Ruikang K.

AU - Nabi, Ghulam

PY - 2015/3/5

Y1 - 2015/3/5

N2 - By combining with the phase sensitive optical coherence tomography (PhS-OCT), vibration and surface acoustic wave (SAW) methods have been reported to provide elastography of skin tissue respectively. However, neither of these two methods can provide the elastography in full skin depth in current systems. This paper presents a feasibility study on an optical coherence elastography method which combines both vibration and SAW in order to give the quantitative mechanical properties of skin tissue with full depth range, including epidermis, dermis and subcutaneous fat. Experiments are carried out on layered tissue mimicking phantoms and in vivo human forearm and palm skin. A ring actuator generates vibration while a line actuator were used to excited SAWs. A PhS-OCT system is employed to provide the ultrahigh sensitive measurement of the generated waves. The experimental results demonstrate that by the combination of vibration and SAW method the full skin bulk mechanical properties can be quantitatively measured and further the elastography can be obtained with a sensing depth from ∼0mm to ∼4mm. This method is promising to apply in clinics where the quantitative elasticity of localized skin diseases is needed to aid the diagnosis and treatment.

AB - By combining with the phase sensitive optical coherence tomography (PhS-OCT), vibration and surface acoustic wave (SAW) methods have been reported to provide elastography of skin tissue respectively. However, neither of these two methods can provide the elastography in full skin depth in current systems. This paper presents a feasibility study on an optical coherence elastography method which combines both vibration and SAW in order to give the quantitative mechanical properties of skin tissue with full depth range, including epidermis, dermis and subcutaneous fat. Experiments are carried out on layered tissue mimicking phantoms and in vivo human forearm and palm skin. A ring actuator generates vibration while a line actuator were used to excited SAWs. A PhS-OCT system is employed to provide the ultrahigh sensitive measurement of the generated waves. The experimental results demonstrate that by the combination of vibration and SAW method the full skin bulk mechanical properties can be quantitatively measured and further the elastography can be obtained with a sensing depth from ∼0mm to ∼4mm. This method is promising to apply in clinics where the quantitative elasticity of localized skin diseases is needed to aid the diagnosis and treatment.

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KW - Elastography

KW - Phase-sensitive optical coherence tomography (PhS-OCT)

KW - Skin disease

KW - Surface acoustic waves (SAWs)

KW - Vibration

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M3 - Conference contribution

AN - SCOPUS:84928579000

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BT - Proceedings Volume 9322

A2 - Tuchin, Valery V.

A2 - Larin, Kirill V.

A2 - Leahy, Martin J.

A2 - Wang, Ruikang K.

PB - SPIE-International Society for Optical Engineering

T2 - SPIE Photonics West 2015

Y2 - 7 February 2015 through 8 February 2015

ER -

Li C, Guan G, Huang Z, Wang RK, Nabi G. Full skin quantitative optical coherence elastography achieved by combining vibration and surface acoustic wave methods. In Tuchin VV, Larin KV, Leahy MJ, Wang RK, editors, Proceedings Volume 9322: Dynamics and Fluctuations in Biomedical Photonics XII. Vol. 9322. SPIE-International Society for Optical Engineering. 2015. 93220O doi: 10.1117/12.2075666

Full skin quantitative optical coherence elastography achieved by combining vibration and surface acoustic wave methods

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

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