Full skin quantitative optical coherence elastography achieved by combining vibration and surface acoustic wave methods

Chunhui Li, Guangying Guan, Zhihong Huang, Ruikang K. Wang, Ghulam Nabi (Lead / Corresponding author)

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

By combining with the phase sensitive optical coherence tomography (PhS-OCT), vibration and surface acoustic wave (SAW) methods have been reported to provide elastography of skin tissue respectively. However, neither of these two methods can provide the elastography in full skin depth in current systems. This paper presents a feasibility study on an optical coherence elastography method which combines both vibration and SAW in order to give the quantitative mechanical properties of skin tissue with full depth range, including epidermis, dermis and subcutaneous fat. Experiments are carried out on layered tissue mimicking phantoms and in vivo human forearm and palm skin. A ring actuator generates vibration while a line actuator were used to excited SAWs. A PhS-OCT system is employed to provide the ultrahigh sensitive measurement of the generated waves. The experimental results demonstrate that by the combination of vibration and SAW method the full skin bulk mechanical properties can be quantitatively measured and further the elastography can be obtained with a sensing depth from ∼0mm to ∼4mm. This method is promising to apply in clinics where the quantitative elasticity of localized skin diseases is needed to aid the diagnosis and treatment.

Original languageEnglish
Title of host publicationProceedings Volume 9322
Subtitle of host publicationDynamics and Fluctuations in Biomedical Photonics XII
EditorsValery V. Tuchin, Kirill V. Larin, Martin J. Leahy, Ruikang K. Wang
PublisherSPIE-International Society for Optical Engineering
Number of pages9
Volume9322
ISBN (Electronic)9781628414127
DOIs
Publication statusPublished - 5 Mar 2015
EventSPIE Photonics West 2015: Dynamics and Fluctuations in Biomedical Photonics XII - Moscone Center, San Francisco, United States
Duration: 7 Feb 20158 Feb 2015
http://spie.org/conferences-and-exhibitions/past-conferences-and-exhibitions/photonics-west-2015 (Link to Conference details)

Publication series

Name
ISSN (Electronic)1605-7422

Conference

ConferenceSPIE Photonics West 2015
CountryUnited States
CitySan Francisco
Period7/02/158/02/15
Internet address

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Keywords

  • Elastic properties
  • Elastography
  • Phase-sensitive optical coherence tomography (PhS-OCT)
  • Skin disease
  • Surface acoustic waves (SAWs)
  • Vibration

Cite this

Li, C., Guan, G., Huang, Z., Wang, R. K., & Nabi, G. (2015). Full skin quantitative optical coherence elastography achieved by combining vibration and surface acoustic wave methods. In V. V. Tuchin, K. V. Larin, M. J. Leahy, & R. K. Wang (Eds.), Proceedings Volume 9322: Dynamics and Fluctuations in Biomedical Photonics XII (Vol. 9322). [93220O] SPIE-International Society for Optical Engineering. https://doi.org/10.1117/12.2075666