Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck

N Thurfjell, P J Coates, L Boldrup, B Lindgren, B Bäcklund, T Uusitalo, D Mahani, E Dabelsteen, A Dahlqvist, B Sjöström, G Roos, B Vojtesek, R Nenutil, K Nylander

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    21 Citations (Scopus)

    Abstract

    Squamous cell carcinoma of the head and neck (HNSCC) is the 6th most common malignancy worldwide with a 5-year survival that has not improved over the last 20-25 years. Factors of prognostic significance for this tumour type include the presence of regional lymph node metastasis and amplification of chromosome 3q21-29, where the p63 gene is located. This gene encodes 6 proteins and is crucial for formation of the oral mucosa, teeth, salivary glands and skin. Each of the 6 different p63 proteins has different characteristics and functions, where some resemble the tumour suppressor protein p53, whilst others have functions that oppose p53.
    Original languageEnglish
    Pages (from-to)49-57
    Number of pages9
    JournalAdvances in Oto-Rhino-Laryngology
    Volume62
    DOIs
    Publication statusPublished - 2005

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  • Cite this

    Thurfjell, N., Coates, P. J., Boldrup, L., Lindgren, B., Bäcklund, B., Uusitalo, T., Mahani, D., Dabelsteen, E., Dahlqvist, A., Sjöström, B., Roos, G., Vojtesek, B., Nenutil, R., & Nylander, K. (2005). Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck. Advances in Oto-Rhino-Laryngology, 62, 49-57. https://doi.org/10.1159/000082464