Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck

N Thurfjell; P J Coates; L Boldrup; B Lindgren; B  Bäcklund; T Uusitalo; D  Mahani; E Dabelsteen; A Dahlqvist; B  Sjöström; G Roos; B  Vojtesek; R Nenutil; K Nylander

doi:10.1159/000082464

Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck

N Thurfjell, P J Coates, L Boldrup, B Lindgren, B Bäcklund, T Uusitalo, D Mahani, E Dabelsteen, A Dahlqvist, B Sjöström, G Roos, B Vojtesek, R Nenutil, K Nylander

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23 Citations (Scopus)

Abstract

Squamous cell carcinoma of the head and neck (HNSCC) is the 6th most common malignancy worldwide with a 5-year survival that has not improved over the last 20-25 years. Factors of prognostic significance for this tumour type include the presence of regional lymph node metastasis and amplification of chromosome 3q21-29, where the p63 gene is located. This gene encodes 6 proteins and is crucial for formation of the oral mucosa, teeth, salivary glands and skin. Each of the 6 different p63 proteins has different characteristics and functions, where some resemble the tumour suppressor protein p53, whilst others have functions that oppose p53.

Original language	English
Pages (from-to)	49-57
Number of pages	9
Journal	Advances in Oto-Rhino-Laryngology
Volume	62
DOIs	https://doi.org/10.1159/000082464
Publication status	Published - 2005

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Thurfjell, N., Coates, P. J., Boldrup, L., Lindgren, B., Bäcklund, B., Uusitalo, T., Mahani, D., Dabelsteen, E., Dahlqvist, A., Sjöström, B., Roos, G., Vojtesek, B., Nenutil, R., & Nylander, K. (2005). Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck. Advances in Oto-Rhino-Laryngology, 62, 49-57. https://doi.org/10.1159/000082464

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abstract = "Squamous cell carcinoma of the head and neck (HNSCC) is the 6th most common malignancy worldwide with a 5-year survival that has not improved over the last 20-25 years. Factors of prognostic significance for this tumour type include the presence of regional lymph node metastasis and amplification of chromosome 3q21-29, where the p63 gene is located. This gene encodes 6 proteins and is crucial for formation of the oral mucosa, teeth, salivary glands and skin. Each of the 6 different p63 proteins has different characteristics and functions, where some resemble the tumour suppressor protein p53, whilst others have functions that oppose p53.",

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Thurfjell, N, Coates, PJ, Boldrup, L, Lindgren, B, Bäcklund, B, Uusitalo, T, Mahani, D, Dabelsteen, E, Dahlqvist, A, Sjöström, B, Roos, G, Vojtesek, B, Nenutil, R & Nylander, K 2005, 'Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck', Advances in Oto-Rhino-Laryngology, vol. 62, pp. 49-57. https://doi.org/10.1159/000082464

TY - JOUR

T1 - Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck

AU - Thurfjell, N

AU - Coates, P J

AU - Boldrup, L

AU - Lindgren, B

AU - Bäcklund, B

AU - Uusitalo, T

AU - Mahani, D

AU - Dabelsteen, E

AU - Dahlqvist, A

AU - Sjöström, B

AU - Roos, G

AU - Vojtesek, B

AU - Nenutil, R

AU - Nylander, K

PY - 2005

Y1 - 2005

N2 - Squamous cell carcinoma of the head and neck (HNSCC) is the 6th most common malignancy worldwide with a 5-year survival that has not improved over the last 20-25 years. Factors of prognostic significance for this tumour type include the presence of regional lymph node metastasis and amplification of chromosome 3q21-29, where the p63 gene is located. This gene encodes 6 proteins and is crucial for formation of the oral mucosa, teeth, salivary glands and skin. Each of the 6 different p63 proteins has different characteristics and functions, where some resemble the tumour suppressor protein p53, whilst others have functions that oppose p53.

AB - Squamous cell carcinoma of the head and neck (HNSCC) is the 6th most common malignancy worldwide with a 5-year survival that has not improved over the last 20-25 years. Factors of prognostic significance for this tumour type include the presence of regional lymph node metastasis and amplification of chromosome 3q21-29, where the p63 gene is located. This gene encodes 6 proteins and is crucial for formation of the oral mucosa, teeth, salivary glands and skin. Each of the 6 different p63 proteins has different characteristics and functions, where some resemble the tumour suppressor protein p53, whilst others have functions that oppose p53.

U2 - 10.1159/000082464

DO - 10.1159/000082464

M3 - Article

C2 - 15608417

SN - 0065-3071

VL - 62

SP - 49

EP - 57

JO - Advances in Oto-Rhino-Laryngology

JF - Advances in Oto-Rhino-Laryngology

ER -

Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck

Abstract

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