Function of the Drosophila TGF-alpha homolog Spitz is controlled by Star and interacts directly with Star

Frank Hsiung, Eric R. Griffis, Amanda Pickup, Maureen A. Powers, Kevin Moses

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    Drosophila Spitz is a homolog of transforming growth factor alpha (TGF-alpha) and is an activating ligand for the EGF receptor (Egfr). It has been shown that Star is required for Spitz activity. Here we show that Star is quantitatively limiting for Spitz production during eye development. We also show that Star and Spitz proteins colocalize in Spitz sending cells and that this association is not coincident with the site of translation--consistent with a function for Star in Spitz processing or transmission. Finally, we have defined minimal sequences within both Spitz and Star that mediate a direct interaction and show that this binding can occur in vivo.
    Original languageEnglish
    Pages (from-to)13-23
    Number of pages11
    JournalMechanisms of Development
    Volume107
    Issue number1-2
    DOIs
    Publication statusPublished - 2001

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