Functional Amyloid and Other Protein Fibers in the Biofilm Matrix

Elliot Erskine; Cait E. MacPhee; Nicola Stanley-Wall

doi:10.1016/j.jmb.2018.07.026

Functional Amyloid and Other Protein Fibers in the Biofilm Matrix

Elliot Erskine, Cait E. MacPhee (Lead / Corresponding author), Nicola Stanley-Wall (Lead / Corresponding author)

Molecular Microbiology

Research output: Contribution to journal › Review article › peer-review

99 Citations (Scopus)

235 Downloads (Pure)

Abstract

Biofilms are ubiquitous in the natural and man-made environment. They are defined as microbes that are encapsulated in an extracellular, self-produced, biofilm matrix. Growing evidence from the genetic and biochemical analysis of single species biofilms has linked the presence of fibrous proteins to a functional biofilm matrix. Some of these fibers have been described as functional amyloid or amyloid-like fibers. Here we provide an overview of the biophysical and biological data for a wide range of protein fibers found in the biofilm matrix of Gram-positive and Gram-negative bacteria.

Original language	English
Pages (from-to)	3642-3656
Number of pages	15
Journal	Journal of Molecular Biology
Volume	430
Issue number	20
Early online date	8 Aug 2018
DOIs	https://doi.org/10.1016/j.jmb.2018.07.026
Publication status	Published - 12 Oct 2018

Keywords

PSM
TasA
biofilm matrix
curli
functional amyloid fibers

ASJC Scopus subject areas

Structural Biology
Molecular Biology

Access to Document

10.1016/j.jmb.2018.07.026Licence: CC BY

Final Published VersionFinal published version, 1.11 MBLicence: CC BY

Cite this

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title = "Functional Amyloid and Other Protein Fibers in the Biofilm Matrix",

abstract = "Biofilms are ubiquitous in the natural and man-made environment. They are defined as microbes that are encapsulated in an extracellular, self-produced, biofilm matrix. Growing evidence from the genetic and biochemical analysis of single species biofilms has linked the presence of fibrous proteins to a functional biofilm matrix. Some of these fibers have been described as functional amyloid or amyloid-like fibers. Here we provide an overview of the biophysical and biological data for a wide range of protein fibers found in the biofilm matrix of Gram-positive and Gram-negative bacteria.",

keywords = "PSM, TasA, biofilm matrix, curli, functional amyloid fibers",

author = "Elliot Erskine and MacPhee, {Cait E.} and Nicola Stanley-Wall",

note = "Work was supported by the Biotechnology and Biological Sciences Research Council [BB/P001335/1; BB/R012415/1; BB/N022254/1]. EE is supported by the Wellcome Institutional Strategic Support Fund (Award no. 097818/Z/11). ",

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doi = "10.1016/j.jmb.2018.07.026",

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T1 - Functional Amyloid and Other Protein Fibers in the Biofilm Matrix

AU - Erskine, Elliot

AU - MacPhee, Cait E.

AU - Stanley-Wall, Nicola

N1 - Work was supported by the Biotechnology and Biological Sciences Research Council [BB/P001335/1; BB/R012415/1; BB/N022254/1]. EE is supported by the Wellcome Institutional Strategic Support Fund (Award no. 097818/Z/11).

PY - 2018/10/12

Y1 - 2018/10/12

N2 - Biofilms are ubiquitous in the natural and man-made environment. They are defined as microbes that are encapsulated in an extracellular, self-produced, biofilm matrix. Growing evidence from the genetic and biochemical analysis of single species biofilms has linked the presence of fibrous proteins to a functional biofilm matrix. Some of these fibers have been described as functional amyloid or amyloid-like fibers. Here we provide an overview of the biophysical and biological data for a wide range of protein fibers found in the biofilm matrix of Gram-positive and Gram-negative bacteria.

AB - Biofilms are ubiquitous in the natural and man-made environment. They are defined as microbes that are encapsulated in an extracellular, self-produced, biofilm matrix. Growing evidence from the genetic and biochemical analysis of single species biofilms has linked the presence of fibrous proteins to a functional biofilm matrix. Some of these fibers have been described as functional amyloid or amyloid-like fibers. Here we provide an overview of the biophysical and biological data for a wide range of protein fibers found in the biofilm matrix of Gram-positive and Gram-negative bacteria.

KW - PSM

KW - TasA

KW - biofilm matrix

KW - curli

KW - functional amyloid fibers

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U2 - 10.1016/j.jmb.2018.07.026

DO - 10.1016/j.jmb.2018.07.026

M3 - Review article

C2 - 30098341

SN - 0022-2836

VL - 430

SP - 3642

EP - 3656

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

IS - 20

ER -

Functional Amyloid and Other Protein Fibers in the Biofilm Matrix

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

IKC Biofilms (Collaboration with University of Southampton via University of Edinburgh)

Architecture of a Biofilm (Joint with University of Edinburgh)

Bacterial Proteins as Formulation Ingredients (Joint with University of Edinburgh)

The structure and function of TasA in the Bacillus subtilis biofilm matrix

Cite this

Functional Amyloid and Other Protein Fibers in the Biofilm Matrix

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

IKC Biofilms (Collaboration with University of Southampton via University of Edinburgh)

Architecture of a Biofilm (Joint with University of Edinburgh)

Bacterial Proteins as Formulation Ingredients (Joint with University of Edinburgh)

Student theses

The structure and function of TasA in the Bacillus subtilis biofilm matrix

Cite this