Functional and clinical consequences of Fc receptor polymorphic and copy number variants

TY - JOUR

T1 - Functional and clinical consequences of Fc receptor polymorphic and copy number variants

AU - Bournazos, S.

AU - Woof, J. M.

AU - Hart, S. P.

AU - Dransfield, I.

PY - 2009

Y1 - 2009

N2 - Receptors for immunoglobulins (Fc receptors) play a central role during an immune response, as they mediate the specific recognition of antigens of almost infinite diversity by leucocytes, thereby linking the humoral and cellular components of immunity. Indeed, engagement of Fc receptors by immunoglobulins initiates a range of immunoregulatory processes that might also play a role in disease pathogenesis. In the circulation, five main types of immunoglobulins (Ig) exist - namely IgG, IgA, IgE, IgM and IgD and receptors with the ability to recognize and bind to IgG (Fc gamma receptor family), IgE (Fc epsilon RI and CD23), IgA (CD89; Fc alpha/mu R) and IgM (Fc alpha/mu R) have been identified and characterized. However, it is astonishing that nearly all the known human Fc receptors display extensive genetic variation with clear implications for their function, thus representing a substantial genetic risk factor for the pathogenesis of a range of chronic inflammatory disorders.

AB - Receptors for immunoglobulins (Fc receptors) play a central role during an immune response, as they mediate the specific recognition of antigens of almost infinite diversity by leucocytes, thereby linking the humoral and cellular components of immunity. Indeed, engagement of Fc receptors by immunoglobulins initiates a range of immunoregulatory processes that might also play a role in disease pathogenesis. In the circulation, five main types of immunoglobulins (Ig) exist - namely IgG, IgA, IgE, IgM and IgD and receptors with the ability to recognize and bind to IgG (Fc gamma receptor family), IgE (Fc epsilon RI and CD23), IgA (CD89; Fc alpha/mu R) and IgM (Fc alpha/mu R) have been identified and characterized. However, it is astonishing that nearly all the known human Fc receptors display extensive genetic variation with clear implications for their function, thus representing a substantial genetic risk factor for the pathogenesis of a range of chronic inflammatory disorders.

KW - Fc receptors

KW - immunoglobulins

KW - polymorphisms

KW - copy number variation

KW - chronic inflammatory diseases

KW - SYSTEMIC-LUPUS-ERYTHEMATOSUS

KW - EPSILON-RI-BETA

KW - GUILLAIN-BARRE-SYNDROME

KW - IDIOPATHIC THROMBOCYTOPENIC PURPURA

KW - HEPARIN-INDUCED THROMBOCYTOPENIA

KW - SINGLE-NUCLEOTIDE POLYMORPHISMS

KW - GAMMA-RIIIB POLYMORPHISMS

KW - HIGH-AFFINITY RECEPTOR

KW - IIA CD32 POLYMORPHISM

KW - SERUM IGE LEVELS

U2 - 10.1111/j.1365-2249.2009.03980.x

DO - 10.1111/j.1365-2249.2009.03980.x

M3 - Review article

C2 - 19604264

SN - 0009-9104

VL - 157

SP - 244

EP - 254

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 2

ER -