Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model

Keyphrases

• Proteomic Analysis 100%
• Functional Analysis 100%
• Filaggrin 100%
• Full-thickness 100%
• Organoid Models 100%
• Skin Organoid 100%
• Organoids 42%
• Keratinocytes 28%
• Knockdown 28%
• Skin Barrier Dysfunction 28%
• Water Content 14%
• Histology 14%
• Healthy Individuals 14%
• Transcriptional Activity 14%
• Gain-of-function mutation 14%
• Mass Spectrometry Analysis 14%
• Primary Cells 14%
• Subtle Change 14%
• Ultrastructure 14%
• Primary Keratinocytes 14%
• Terminal Differentiation 14%
• Stratum Corneum 14%
• Atopic Eczema 14%
• Keratohyalin Granules 14%
• Absence of Evidence 14%
• Major Risk Factors 14%
• Inflammatory Disorders 14%
• Specific Mechanisms 14%
• SiRNA Knockdown 14%
• Primary Fibroblasts 14%
• Transforming Growth factor-β1 (TGF-β1) 14%
• Future Therapies 14%
• Genetic Effects 14%
• Barrier Impairment 14%
• Haploinsufficiency 14%
• Innate Immunity 14%
• Adaptive Immunity 14%
• Transepidermal Water Loss 14%
• AKT1 14%
• Human Donor 14%
• Axon Guidance 14%
• Histological Measurement 14%
• Biochemical Measurements 14%
• Protein Clusters 14%
• Pruritus 14%
• Biological Replicates 14%
• Gene Pathway Analysis 14%
• Atopic Inflammation 14%
• Gene Ontology Analysis 14%
• Functional Measurement 14%
• Translational Activity 14%
• Thickness Reduction 14%
• Immune Crosstalk 14%
• Caspase-14 14%
• Epidermal Ceramides 14%
• Dye Penetration 14%
• Dermokine 14%

Medicine and Dentistry

• Filaggrin 100%
• Organoid 100%
• Proteomics 100%
• Keratinocyte 42%
• In Vitro 14%
• Stratum Corneum 14%
• Loss of Function Mutation 14%
• Atopic Dermatitis 14%
• Inflammatory Disorder 14%
• Small Interfering RNA 14%
• Axon Guidance 14%
• Mass Spectrum 14%
• Adaptive Immunity 14%
• Haploinsufficiency 14%
• Transforming Growth Factor Beta1 14%
• Ceramide 14%
• Pruritus 14%
• Skin Water Loss 14%
• Keratohyalin 14%
• Ultrastructure 14%
• Caspase 14 14%
• Matched Donor 14%
• Fibroblast 14%

Immunology and Microbiology

• Organoid 100%
• Proteomics 100%
• Keratinocyte 60%
• Inflammatory Disorder 20%
• Adaptive Immune System 20%
• Stratum Corneum 20%
• Eczema 20%
• Loss of Function Mutation 20%
• Caspase 20%
• Transforming Growth Factor Beta1 20%
• Haploinsufficiency 20%
• Skin Water Loss 20%
• Gene Ontology 20%
• Axon Guidance 20%
• Fibroblast 20%
• Water Content 20%