Functions and mechanisms of fibroblast growth factor (FGF) signalling in Drosophila melanogaster

Villö Muha, Hans-Arno J. Muller

    Research output: Contribution to journalReview article

    25 Citations (Scopus)

    Abstract

    Intercellular signalling via growth factors plays an important role in controlling cell differentiation and cell movements during the development of multicellular animals. Fibroblast Growth Factor (FGF) signalling induces changes in cellular behaviour allowing cells in the embryo to move, to survive, to divide or to differentiate. Several examples argue that FGF signalling is used in multi-step morphogenetic processes to achieve and maintain a transitional state of the cells required for the control of cell fate. In the genetic model Drosophila melanogaster, FGF signalling via the receptor tyrosine kinases Heartless (Htl) and Breathless (Btl) is particularly well studied. These FGF receptors affect gene expression, cell shape and cell-cell interactions during mesoderm layer formation, caudal visceral muscle (CVM) formation, tracheal morphogenesis and glia differentiation. Here, we will address the current knowledge of the biological functions of FGF signalling in the fly on the tissue, at a cellular and molecular level.

    Original languageEnglish
    Pages (from-to)5920-5937
    Number of pages18
    JournalInternational Journal of Molecular Sciences
    Volume14
    Issue number3
    DOIs
    Publication statusPublished - Mar 2013

    Keywords

    • cell migration
    • development
    • SYSTEM
    • differentiation
    • fibroblast growth factor
    • EMBRYONIC MESODERM
    • BRANCHING MORPHOGENESIS
    • MESODERM MIGRATION
    • TRACHEAL CELL-MIGRATION
    • HEARTLESS
    • cell signalling
    • ENCODES
    • HEPARAN-SULFATE
    • Drosophila
    • RECEPTOR HOMOLOG
    • EXCHANGE FACTOR PEBBLE

    Cite this

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    title = "Functions and mechanisms of fibroblast growth factor (FGF) signalling in Drosophila melanogaster",
    abstract = "Intercellular signalling via growth factors plays an important role in controlling cell differentiation and cell movements during the development of multicellular animals. Fibroblast Growth Factor (FGF) signalling induces changes in cellular behaviour allowing cells in the embryo to move, to survive, to divide or to differentiate. Several examples argue that FGF signalling is used in multi-step morphogenetic processes to achieve and maintain a transitional state of the cells required for the control of cell fate. In the genetic model Drosophila melanogaster, FGF signalling via the receptor tyrosine kinases Heartless (Htl) and Breathless (Btl) is particularly well studied. These FGF receptors affect gene expression, cell shape and cell-cell interactions during mesoderm layer formation, caudal visceral muscle (CVM) formation, tracheal morphogenesis and glia differentiation. Here, we will address the current knowledge of the biological functions of FGF signalling in the fly on the tissue, at a cellular and molecular level.",
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    year = "2013",
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    volume = "14",
    pages = "5920--5937",
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    Functions and mechanisms of fibroblast growth factor (FGF) signalling in Drosophila melanogaster. / Muha, Villö; Muller, Hans-Arno J.

    In: International Journal of Molecular Sciences, Vol. 14, No. 3, 03.2013, p. 5920-5937.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - Functions and mechanisms of fibroblast growth factor (FGF) signalling in Drosophila melanogaster

    AU - Muha, Villö

    AU - Muller, Hans-Arno J.

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    N2 - Intercellular signalling via growth factors plays an important role in controlling cell differentiation and cell movements during the development of multicellular animals. Fibroblast Growth Factor (FGF) signalling induces changes in cellular behaviour allowing cells in the embryo to move, to survive, to divide or to differentiate. Several examples argue that FGF signalling is used in multi-step morphogenetic processes to achieve and maintain a transitional state of the cells required for the control of cell fate. In the genetic model Drosophila melanogaster, FGF signalling via the receptor tyrosine kinases Heartless (Htl) and Breathless (Btl) is particularly well studied. These FGF receptors affect gene expression, cell shape and cell-cell interactions during mesoderm layer formation, caudal visceral muscle (CVM) formation, tracheal morphogenesis and glia differentiation. Here, we will address the current knowledge of the biological functions of FGF signalling in the fly on the tissue, at a cellular and molecular level.

    AB - Intercellular signalling via growth factors plays an important role in controlling cell differentiation and cell movements during the development of multicellular animals. Fibroblast Growth Factor (FGF) signalling induces changes in cellular behaviour allowing cells in the embryo to move, to survive, to divide or to differentiate. Several examples argue that FGF signalling is used in multi-step morphogenetic processes to achieve and maintain a transitional state of the cells required for the control of cell fate. In the genetic model Drosophila melanogaster, FGF signalling via the receptor tyrosine kinases Heartless (Htl) and Breathless (Btl) is particularly well studied. These FGF receptors affect gene expression, cell shape and cell-cell interactions during mesoderm layer formation, caudal visceral muscle (CVM) formation, tracheal morphogenesis and glia differentiation. Here, we will address the current knowledge of the biological functions of FGF signalling in the fly on the tissue, at a cellular and molecular level.

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    KW - MESODERM MIGRATION

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    KW - ENCODES

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