Functions and regulation of the serine/threonine protein kinase CK1 family: moving beyond promiscuity

Luke J. Fulcher (Lead / Corresponding author), Gopal P. Sapkota (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

34 Downloads (Pure)

Abstract

Regarded as constitutively active enzymes, known to participate in many, diverse biological processes, the intracellular regulation bestowed on the CK1 family of serine/threonine protein kinases is critically important, yet poorly understood. Here, we provide an overview of the known CK1-dependent cellular functions and review the emerging roles of CK1-regulating proteins in these processes. We go on to discuss the advances, limitations and pitfalls that CK1 researchers encounter when attempting to define relationships between CK1 isoforms and their substrates, and the challenges associated with ascertaining the correct physiological CK1 isoform for the substrate of interest. With increasing interest in CK1 isoforms as therapeutic targets, methods of selectively inhibiting CK1 isoform-specific processes is warranted, yet challenging to achieve given their participation in such a vast plethora of signalling pathways. Here, we discuss how one might shut down CK1-specific processes, without impacting other aspects of CK1 biology.
Original languageEnglish
Pages (from-to)4603-4621
Number of pages19
JournalBiochemical Journal
Volume477
Issue number23
Early online date11 Dec 2020
DOIs
Publication statusPublished - Dec 2020

Keywords

  • CK1
  • FAM83
  • Wnt
  • p53
  • circadian rhythm
  • hedgehog
  • hippo
  • cell cycle
  • apoptosis
  • kinase

Fingerprint Dive into the research topics of 'Functions and regulation of the serine/threonine protein kinase CK1 family: moving beyond promiscuity'. Together they form a unique fingerprint.

Cite this