Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa

Kirsty M. O. Brown, Sarah R. Bujac, Evleen T. Mann, David A. Campbell, Michael J. Stubbins, John E. Blundell

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    Background: A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). Methods: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. Results: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN. Conclusions: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes. © 2007 Society of Biological Psychiatry.
    Original languageEnglish
    Pages (from-to)367-373
    Number of pages7
    JournalBiological Psychiatry
    Issue number3
    Publication statusPublished - 1 Feb 2007


    • Adult
    • Alleles
    • Anorexia Nervosa
    • DNA
    • Female
    • Gene Frequency
    • Genotype
    • Great Britain
    • Humans
    • Linkage Disequilibrium
    • Odds Ratio
    • Polymorphism, Genetic
    • Psychiatric Status Rating Scales
    • Receptor, Serotonin, 5-HT1D
    • Receptors, Opioid, delta


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