Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa

Kirsty M. O. Brown; Sarah R. Bujac; Evleen T. Mann; David A. Campbell; Michael J. Stubbins; John E. Blundell

doi:10.1016/j.biopsych.2006.04.007

Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa

Kirsty M. O. Brown, Sarah R. Bujac, Evleen T. Mann, David A. Campbell, Michael J. Stubbins, John E. Blundell

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). Methods: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. Results: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN. Conclusions: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes. © 2007 Society of Biological Psychiatry.

Original language	English
Pages (from-to)	367-373
Number of pages	7
Journal	Biological Psychiatry
Volume	61
Issue number	3
DOIs	https://doi.org/10.1016/j.biopsych.2006.04.007
Publication status	Published - 1 Feb 2007

Keywords

Adult
Alleles
Anorexia Nervosa
DNA
Female
Gene Frequency
Genotype
Great Britain
Humans
Linkage Disequilibrium
Odds Ratio
Polymorphism, Genetic
Psychiatric Status Rating Scales
Receptor, Serotonin, 5-HT1D
Receptors, Opioid, delta

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10.1016/j.biopsych.2006.04.007

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title = "Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa",

abstract = "Background: A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). Methods: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. Results: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN. Conclusions: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes. {\textcopyright} 2007 Society of Biological Psychiatry.",

keywords = "Adult, Alleles, Anorexia Nervosa, DNA, Female, Gene Frequency, Genotype, Great Britain, Humans, Linkage Disequilibrium, Odds Ratio, Polymorphism, Genetic, Psychiatric Status Rating Scales, Receptor, Serotonin, 5-HT1D, Receptors, Opioid, delta",

author = "Brown, {Kirsty M. O.} and Bujac, {Sarah R.} and Mann, {Evleen T.} and Campbell, {David A.} and Stubbins, {Michael J.} and Blundell, {John E.}",

year = "2007",

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doi = "10.1016/j.biopsych.2006.04.007",

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T1 - Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa

AU - Brown, Kirsty M. O.

AU - Bujac, Sarah R.

AU - Mann, Evleen T.

AU - Campbell, David A.

AU - Stubbins, Michael J.

AU - Blundell, John E.

PY - 2007/2/1

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N2 - Background: A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). Methods: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. Results: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN. Conclusions: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes. © 2007 Society of Biological Psychiatry.

AB - Background: A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). Methods: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. Results: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN. Conclusions: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes. © 2007 Society of Biological Psychiatry.

KW - Adult

KW - Alleles

KW - Anorexia Nervosa

KW - DNA

KW - Female

KW - Gene Frequency

KW - Genotype

KW - Great Britain

KW - Humans

KW - Linkage Disequilibrium

KW - Odds Ratio

KW - Polymorphism, Genetic

KW - Psychiatric Status Rating Scales

KW - Receptor, Serotonin, 5-HT1D

KW - Receptors, Opioid, delta

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DO - 10.1016/j.biopsych.2006.04.007

M3 - Article

C2 - 16806108

SN - 0006-3223

VL - 61

SP - 367

EP - 373

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 3

ER -

Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa

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