TY - JOUR
T1 - Future prospects for the chemotherapy of human trypanosomiasis
T2 - 1. Novel approaches to the chemotherapy of trypanosomiasis
AU - Fairlamb, Alan H.
N1 - Funding Information:
Acknowledgements I thank the many scientists with whom I have collaborated on aspectosf this researcha nd the WellcomeT rust, the Medical Research Council, the National Institutes of Health and the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases for financial support.
PY - 1990/9
Y1 - 1990/9
N2 - Chemotherapy of trypanosomiasis and leishmaniasis is far from satisfactory and the discovery of new drugs has been slow. Emphasis on the empirical approach to drug development is now shifting towards a more rational, directed approach, which employs the modern tools of science. This is illustrated with respect to the newly discovered drug target, trypanothione, a unique metabolite which is critical for survival of Trypanosoma and Leishmania and absent from the host.
AB - Chemotherapy of trypanosomiasis and leishmaniasis is far from satisfactory and the discovery of new drugs has been slow. Emphasis on the empirical approach to drug development is now shifting towards a more rational, directed approach, which employs the modern tools of science. This is illustrated with respect to the newly discovered drug target, trypanothione, a unique metabolite which is critical for survival of Trypanosoma and Leishmania and absent from the host.
UR - http://www.scopus.com/inward/record.url?scp=0025187178&partnerID=8YFLogxK
U2 - 10.1016/0035-9203(90)90124-W
DO - 10.1016/0035-9203(90)90124-W
M3 - Article
C2 - 2278053
AN - SCOPUS:0025187178
SN - 0035-9203
VL - 84
SP - 613
EP - 617
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - 5
ER -
