Future prospects for the chemotherapy of human trypanosomiasis: 1. Novel approaches to the chemotherapy of trypanosomiasis

TY - JOUR

T1 - Future prospects for the chemotherapy of human trypanosomiasis

T2 - 1. Novel approaches to the chemotherapy of trypanosomiasis

AU - Fairlamb, Alan H.

N1 - Funding Information: Acknowledgements I thank the many scientists with whom I have collaborated on aspectosf this researcha nd the WellcomeT rust, the Medical Research Council, the National Institutes of Health and the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases for financial support.

PY - 1990/9

Y1 - 1990/9

N2 - Chemotherapy of trypanosomiasis and leishmaniasis is far from satisfactory and the discovery of new drugs has been slow. Emphasis on the empirical approach to drug development is now shifting towards a more rational, directed approach, which employs the modern tools of science. This is illustrated with respect to the newly discovered drug target, trypanothione, a unique metabolite which is critical for survival of Trypanosoma and Leishmania and absent from the host.

AB - Chemotherapy of trypanosomiasis and leishmaniasis is far from satisfactory and the discovery of new drugs has been slow. Emphasis on the empirical approach to drug development is now shifting towards a more rational, directed approach, which employs the modern tools of science. This is illustrated with respect to the newly discovered drug target, trypanothione, a unique metabolite which is critical for survival of Trypanosoma and Leishmania and absent from the host.

UR - https://www.scopus.com/pages/publications/0025187178

U2 - 10.1016/0035-9203(90)90124-W

DO - 10.1016/0035-9203(90)90124-W

M3 - Article

C2 - 2278053

AN - SCOPUS:0025187178

SN - 0035-9203

VL - 84

SP - 613

EP - 617

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 5

ER -