GABAA receptor subtype involvement in addictive behaviour

D. N. Stephens (Lead / Corresponding author), S. L. King, J. J. Lambert, D. Belelli, T. Duka

    Research output: Contribution to journalReview article

    29 Citations (Scopus)
    158 Downloads (Pure)

    Abstract

    GABAA receptors form the major class of inhibitory neurotransmitter receptors in the mammalian brain. This review sets out to summarise the evidence that variations in genes encoding GABAA receptor isoforms are associated with aspects of addictive behaviour in humans, while animal models of addictive behaviour also implicate certain subtypes of GABAA receptor. In addition to outlining the evidence for the involvement of specific subtypes in addiction, we summarise the particular contributions of these isoforms in control over the functioning of brain circuits, especially the mesolimbic system, and make a first attempt to bring together evidence from several fields to understanding potential involvement of GABAA Receptor Subtypes in addictive behaviour. While the weight of the published literature is on alcohol dependency, the underlying principles outlined are relevant across a number of different aspects of addictive behaviour.

    Original languageEnglish
    Pages (from-to)149-184
    Number of pages36
    JournalGenes, Brain and Behavior
    Volume16
    Issue number1
    Early online date19 Aug 2016
    DOIs
    Publication statusPublished - Jan 2017

    Keywords

    • alcohol
    • psychostimulant
    • nucleus accumbens
    • gene association
    • gene knockout
    • animal model
    • reward
    • impulsivity
    • benzodiazepine
    • conduct disorder
    • electrophysiology

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