GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes

H. A. J. Castleden, B. Shields, P. J. Bingley, A. J. K. Williams, M. Sampson, M. Walker, J. M. Gibson, M. I. McCarthy, G. A. Hitman, J. C. Levy, A. T. Hattersley, B. Vaidya, E. R. Pearson (Lead / Corresponding author)

Research output: Contribution to journalArticle

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Abstract

Aims: A subset of patients who present as if they have Type 2 diabetes have positive pancreatic autoantibodies, and have been referred to as having latent autoimmune diabetes in adults (LADA). We assessed the prevalence and clinical characteristics of patients with glutamic acid decarboxylase antibodies (GADA) in a cohort clinically selected for Type 2 diabetes and determined the presence of diabetes and GADA in their first-degree relatives.

Methods: GADA were measured in 2059 subjects, not known to be related, and clinically selected as having Type 2 diabetes for genetic studies. Clinical characteristics were compared in GADA positive and GADA negative subjects. Diabetes and GAD antibody status were compared in 208 first-degree relatives of GADA positive and GADA negative probands.

Results: Of the subjects, 136 (7%) were GADA positive. Compared with the GADA negative subjects, they were slimmer (P < 0.001), diagnosed at a younger age (P = 0.011) and progressed to insulin faster (P < 0.001). Thirty-three per cent of GADA positive subjects had a first-degree relative with diabetes compared with 42% of GADA negative subjects (P = 0.034). The overall prevalence of GADA was similar in the first-degree relatives of GADA positive and GADA negative probands (4 v 5%), and 19 of 22 (86%) diabetic relatives of GADA positive probands were GADA negative.

Conclusion: Despite clinically selecting a Type 2 diabetes cohort, 7% were GADA positive with an altered phenotype. These GADA positive patients had a strong family history of non-autoimmune diabetes. This suggests that, in this subgroup of patients, autoimmune pancreatic β-cell destruction occurs on a background of Type 2 diabetes genetic susceptibility.

Original languageEnglish
Pages (from-to)834-838
Number of pages5
JournalDiabetic Medicine
Volume23
Issue number8
Early online date26 Jun 2006
DOIs
Publication statusPublished - Aug 2006

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Glutamate Decarboxylase
Type 2 Diabetes Mellitus
Antibodies

Keywords

  • Familial inheritance
  • Glutamic acid decarboxylase antibodies
  • Latent autoimmune diabetes in adults
  • Type 1 diabetes
  • Type 2 diabetes

Cite this

Castleden, H. A. J., Shields, B., Bingley, P. J., Williams, A. J. K., Sampson, M., Walker, M., ... Pearson, E. R. (2006). GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes. Diabetic Medicine, 23(8), 834-838. https://doi.org/10.1111/j.1464-5491.2006.01915.x
Castleden, H. A. J. ; Shields, B. ; Bingley, P. J. ; Williams, A. J. K. ; Sampson, M. ; Walker, M. ; Gibson, J. M. ; McCarthy, M. I. ; Hitman, G. A. ; Levy, J. C. ; Hattersley, A. T. ; Vaidya, B. ; Pearson, E. R. / GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes. In: Diabetic Medicine. 2006 ; Vol. 23, No. 8. pp. 834-838.
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abstract = "Aims: A subset of patients who present as if they have Type 2 diabetes have positive pancreatic autoantibodies, and have been referred to as having latent autoimmune diabetes in adults (LADA). We assessed the prevalence and clinical characteristics of patients with glutamic acid decarboxylase antibodies (GADA) in a cohort clinically selected for Type 2 diabetes and determined the presence of diabetes and GADA in their first-degree relatives.Methods: GADA were measured in 2059 subjects, not known to be related, and clinically selected as having Type 2 diabetes for genetic studies. Clinical characteristics were compared in GADA positive and GADA negative subjects. Diabetes and GAD antibody status were compared in 208 first-degree relatives of GADA positive and GADA negative probands.Results: Of the subjects, 136 (7{\%}) were GADA positive. Compared with the GADA negative subjects, they were slimmer (P < 0.001), diagnosed at a younger age (P = 0.011) and progressed to insulin faster (P < 0.001). Thirty-three per cent of GADA positive subjects had a first-degree relative with diabetes compared with 42{\%} of GADA negative subjects (P = 0.034). The overall prevalence of GADA was similar in the first-degree relatives of GADA positive and GADA negative probands (4 v 5{\%}), and 19 of 22 (86{\%}) diabetic relatives of GADA positive probands were GADA negative.Conclusion: Despite clinically selecting a Type 2 diabetes cohort, 7{\%} were GADA positive with an altered phenotype. These GADA positive patients had a strong family history of non-autoimmune diabetes. This suggests that, in this subgroup of patients, autoimmune pancreatic β-cell destruction occurs on a background of Type 2 diabetes genetic susceptibility.",
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Castleden, HAJ, Shields, B, Bingley, PJ, Williams, AJK, Sampson, M, Walker, M, Gibson, JM, McCarthy, MI, Hitman, GA, Levy, JC, Hattersley, AT, Vaidya, B & Pearson, ER 2006, 'GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes', Diabetic Medicine, vol. 23, no. 8, pp. 834-838. https://doi.org/10.1111/j.1464-5491.2006.01915.x

GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes. / Castleden, H. A. J.; Shields, B.; Bingley, P. J.; Williams, A. J. K.; Sampson, M.; Walker, M.; Gibson, J. M.; McCarthy, M. I.; Hitman, G. A.; Levy, J. C.; Hattersley, A. T.; Vaidya, B.; Pearson, E. R. (Lead / Corresponding author).

In: Diabetic Medicine, Vol. 23, No. 8, 08.2006, p. 834-838.

Research output: Contribution to journalArticle

TY - JOUR

T1 - GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes

AU - Castleden, H. A. J.

AU - Shields, B.

AU - Bingley, P. J.

AU - Williams, A. J. K.

AU - Sampson, M.

AU - Walker, M.

AU - Gibson, J. M.

AU - McCarthy, M. I.

AU - Hitman, G. A.

AU - Levy, J. C.

AU - Hattersley, A. T.

AU - Vaidya, B.

AU - Pearson, E. R.

PY - 2006/8

Y1 - 2006/8

N2 - Aims: A subset of patients who present as if they have Type 2 diabetes have positive pancreatic autoantibodies, and have been referred to as having latent autoimmune diabetes in adults (LADA). We assessed the prevalence and clinical characteristics of patients with glutamic acid decarboxylase antibodies (GADA) in a cohort clinically selected for Type 2 diabetes and determined the presence of diabetes and GADA in their first-degree relatives.Methods: GADA were measured in 2059 subjects, not known to be related, and clinically selected as having Type 2 diabetes for genetic studies. Clinical characteristics were compared in GADA positive and GADA negative subjects. Diabetes and GAD antibody status were compared in 208 first-degree relatives of GADA positive and GADA negative probands.Results: Of the subjects, 136 (7%) were GADA positive. Compared with the GADA negative subjects, they were slimmer (P < 0.001), diagnosed at a younger age (P = 0.011) and progressed to insulin faster (P < 0.001). Thirty-three per cent of GADA positive subjects had a first-degree relative with diabetes compared with 42% of GADA negative subjects (P = 0.034). The overall prevalence of GADA was similar in the first-degree relatives of GADA positive and GADA negative probands (4 v 5%), and 19 of 22 (86%) diabetic relatives of GADA positive probands were GADA negative.Conclusion: Despite clinically selecting a Type 2 diabetes cohort, 7% were GADA positive with an altered phenotype. These GADA positive patients had a strong family history of non-autoimmune diabetes. This suggests that, in this subgroup of patients, autoimmune pancreatic β-cell destruction occurs on a background of Type 2 diabetes genetic susceptibility.

AB - Aims: A subset of patients who present as if they have Type 2 diabetes have positive pancreatic autoantibodies, and have been referred to as having latent autoimmune diabetes in adults (LADA). We assessed the prevalence and clinical characteristics of patients with glutamic acid decarboxylase antibodies (GADA) in a cohort clinically selected for Type 2 diabetes and determined the presence of diabetes and GADA in their first-degree relatives.Methods: GADA were measured in 2059 subjects, not known to be related, and clinically selected as having Type 2 diabetes for genetic studies. Clinical characteristics were compared in GADA positive and GADA negative subjects. Diabetes and GAD antibody status were compared in 208 first-degree relatives of GADA positive and GADA negative probands.Results: Of the subjects, 136 (7%) were GADA positive. Compared with the GADA negative subjects, they were slimmer (P < 0.001), diagnosed at a younger age (P = 0.011) and progressed to insulin faster (P < 0.001). Thirty-three per cent of GADA positive subjects had a first-degree relative with diabetes compared with 42% of GADA negative subjects (P = 0.034). The overall prevalence of GADA was similar in the first-degree relatives of GADA positive and GADA negative probands (4 v 5%), and 19 of 22 (86%) diabetic relatives of GADA positive probands were GADA negative.Conclusion: Despite clinically selecting a Type 2 diabetes cohort, 7% were GADA positive with an altered phenotype. These GADA positive patients had a strong family history of non-autoimmune diabetes. This suggests that, in this subgroup of patients, autoimmune pancreatic β-cell destruction occurs on a background of Type 2 diabetes genetic susceptibility.

KW - Familial inheritance

KW - Glutamic acid decarboxylase antibodies

KW - Latent autoimmune diabetes in adults

KW - Type 1 diabetes

KW - Type 2 diabetes

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U2 - 10.1111/j.1464-5491.2006.01915.x

DO - 10.1111/j.1464-5491.2006.01915.x

M3 - Article

VL - 23

SP - 834

EP - 838

JO - Diabetic Medicine

JF - Diabetic Medicine

SN - 0742-3071

IS - 8

ER -