Gastric Cancer

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

Gastric cancer in eastern populations tends to occur at a younger age, and patients present at an earlier stage and generally have fewer co-morbid medical conditions. Elucidation of the molecular pathogenesis of gastric cancer has provided targets for novel rationally designed targeted anti-cancer drugs. Endoscopic ultrasonography provides accurate T staging and in particular, can accurately predict mucosal and sub-mucosal invasion of gastric cancer. Cytotoxic chemotherapy is an effective palliative treatment for advanced gastric cancer, providing symptomatic and quality-of-life benefits and prolongation of survival. Immune checkpoint inhibitors have shown promising activity, with durable responses seen in a subset of patients with advanced gastric cancer in recent clinical trials. The conclusion on surgical management of gastric cancer is that only complete resection can currently offer a cure for the disease, and the trend towards more careful selection of patients suitable for curative resection must be welcomed.
Original languageEnglish
Title of host publicationTreatment of Cancer
EditorsPat Price, Karol Sikora
Place of PublicationBoca Raton
PublisherCRC Press-Taylor & Francis Group
Chapter12
Number of pages10
Edition7th
ISBN (Electronic)9780429026638
DOIs
Publication statusPublished - 25 Nov 2020

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