Gastric Cancer

Mark Baxter; Russell Petty

doi:10.1201/9780429026638-12

Gastric Cancer

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Abstract

Gastric cancer in eastern populations tends to occur at a younger age, and patients present at an earlier stage and generally have fewer co-morbid medical conditions. Elucidation of the molecular pathogenesis of gastric cancer has provided targets for novel rationally designed targeted anti-cancer drugs. Endoscopic ultrasonography provides accurate T staging and in particular, can accurately predict mucosal and sub-mucosal invasion of gastric cancer. Cytotoxic chemotherapy is an effective palliative treatment for advanced gastric cancer, providing symptomatic and quality-of-life benefits and prolongation of survival. Immune checkpoint inhibitors have shown promising activity, with durable responses seen in a subset of patients with advanced gastric cancer in recent clinical trials. The conclusion on surgical management of gastric cancer is that only complete resection can currently offer a cure for the disease, and the trend towards more careful selection of patients suitable for curative resection must be welcomed.

Original language	English
Title of host publication	Treatment of Cancer
Editors	Pat Price, Karol Sikora
Place of Publication	Boca Raton
Publisher	CRC Press-Taylor & Francis Group
Chapter	12
Number of pages	10
Edition	7th
ISBN (Electronic)	9780429026638
DOIs	https://doi.org/10.1201/9780429026638-12
Publication status	Published - 25 Nov 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1201/9780429026638-12

https://www.taylorfrancis.com/chapters/gastric-cancer-mark-baxter-russell-petty/e/10.1201/9780429026638-12?context=ubx&refId=c55bd605-4388-4ed0-8287-ecac82668f9c

Identifying and Validating Predictive Biomarkers in Advanced Oesophagael Adenocarcinoma - A Springboard to REAListic Medicine (BE-REAL)
Baxter, M. (Investigator)
1/10/20 → 29/02/24
Project: Research

Cite this

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title = "Gastric Cancer",

abstract = "Gastric cancer in eastern populations tends to occur at a younger age, and patients present at an earlier stage and generally have fewer co-morbid medical conditions. Elucidation of the molecular pathogenesis of gastric cancer has provided targets for novel rationally designed targeted anti-cancer drugs. Endoscopic ultrasonography provides accurate T staging and in particular, can accurately predict mucosal and sub-mucosal invasion of gastric cancer. Cytotoxic chemotherapy is an effective palliative treatment for advanced gastric cancer, providing symptomatic and quality-of-life benefits and prolongation of survival. Immune checkpoint inhibitors have shown promising activity, with durable responses seen in a subset of patients with advanced gastric cancer in recent clinical trials. The conclusion on surgical management of gastric cancer is that only complete resection can currently offer a cure for the disease, and the trend towards more careful selection of patients suitable for curative resection must be welcomed.",

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AU - Petty, Russell

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AB - Gastric cancer in eastern populations tends to occur at a younger age, and patients present at an earlier stage and generally have fewer co-morbid medical conditions. Elucidation of the molecular pathogenesis of gastric cancer has provided targets for novel rationally designed targeted anti-cancer drugs. Endoscopic ultrasonography provides accurate T staging and in particular, can accurately predict mucosal and sub-mucosal invasion of gastric cancer. Cytotoxic chemotherapy is an effective palliative treatment for advanced gastric cancer, providing symptomatic and quality-of-life benefits and prolongation of survival. Immune checkpoint inhibitors have shown promising activity, with durable responses seen in a subset of patients with advanced gastric cancer in recent clinical trials. The conclusion on surgical management of gastric cancer is that only complete resection can currently offer a cure for the disease, and the trend towards more careful selection of patients suitable for curative resection must be welcomed.

U2 - 10.1201/9780429026638-12

DO - 10.1201/9780429026638-12

M3 - Chapter (peer-reviewed)

BT - Treatment of Cancer

A2 - Price, Pat

A2 - Sikora, Karol

PB - CRC Press-Taylor & Francis Group

CY - Boca Raton

ER -

Gastric Cancer

Abstract

UN SDGs

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Projects

Identifying and Validating Predictive Biomarkers in Advanced Oesophagael Adenocarcinoma - A Springboard to REAListic Medicine (BE-REAL)

Cite this