Gastroesophageal adenocarcinoma in older adults: A comprehensive narrative review of management by the young international society of geriatric oncology

Mark A. Baxter (Lead / Corresponding author), Joana Marinho, Enrique Soto-Perez-de-Celis, Maria Grazia Rodriquenz, Sukeshi Patel Arora, Wendy Chan Wing Lok, Yung-Yu Shih, Gabor Liposits, Shane O'Hanlon, Russell D. Petty

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Abstract

Gastroesophageal adenocarcinoma is a disease of older adults with very poor survival rates. Its incidence has risen dramatically across the world in recent decades. Current treatment approaches for older adults are based largely on extrapolated evidence from clinical trials conducted in younger and fitter participants than those more commonly encountered in clinical practice. Understanding how to apply available evidence to our patients in the clinic setting is essential given the high morbidity of both curative and palliative treatment. This review aims to use available data to inform the management of an older adult with gastroesophageal adenocarcinoma.

Original languageEnglish
Pages (from-to)7-19
Number of pages13
JournalJournal of Geriatric Oncology
Volume13
Issue number1
Early online date18 Sep 2021
DOIs
Publication statusPublished - Jan 2022

Keywords

  • Frailty
  • Gastroesophageal adenocarcinoma
  • Multi-disciplinary
  • Real-world
  • Toxicity

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