Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy

S. L. Parsons, S. A. Watson, H. M. Collins, N. R. Griffin, P. A. Clarke, R. J. C. Steele

    Research output: Contribution to journalArticle

    114 Citations (Scopus)

    Abstract

    The aim of the study was to investigate expression of the active and inactive gelatinases (MMP-2 and -9) in colorectal neoplasia and gastric cancer compared with normal mucosa. A total of 53 colorectal cancers and corresponding normal mucosa were studied using gelatin zymography as well as 15 colorectal adenomas and 13 gastric cancers with corresponding normal mucosa. Overexpression of all the gelatinases occurs in both colorectal and gastric cancer, with activation of MMP-2 appearing to be a feature of the malignant phenotype. Overexpression of MMP-9 occurs in colorectal adenomas. The gelatinases are overexpressed in gastrointestinal neoplasia, suggesting that these enzymes may have an important role in tumour invasion and metastasis.
    Original languageEnglish
    Pages (from-to)1495-1502
    Number of pages8
    JournalBritish Journal of Cancer
    Volume78
    Issue number11
    DOIs
    Publication statusPublished - 1998

    Keywords

    • Adenoma
    • Collagenases
    • Colorectal Neoplasms
    • Gastric Mucosa
    • Gelatinases
    • Humans
    • Intestinal Mucosa
    • Matrix Metalloproteinase 2
    • Matrix Metalloproteinase 9
    • Metalloendopeptidases
    • Neoplasm Proteins
    • Neoplasm Staging
    • Stomach Neoplasms

    Fingerprint Dive into the research topics of 'Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy'. Together they form a unique fingerprint.

  • Cite this

    Parsons, S. L., Watson, S. A., Collins, H. M., Griffin, N. R., Clarke, P. A., & Steele, R. J. C. (1998). Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy. British Journal of Cancer, 78(11), 1495-1502. https://doi.org/10.1038/bjc.1998.712