Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy

S. L. Parsons; S. A. Watson; H. M. Collins; N. R. Griffin; P. A. Clarke; R. J. C. Steele

doi:10.1038/bjc.1998.712

Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy

S. L. Parsons
, S. A. Watson
, H. M. Collins
, N. R. Griffin
, P. A. Clarke
, R. J. C. Steele

Research output: Contribution to journal › Article › peer-review

123 Citations (Scopus)

Abstract

The aim of the study was to investigate expression of the active and inactive gelatinases (MMP-2 and -9) in colorectal neoplasia and gastric cancer compared with normal mucosa. A total of 53 colorectal cancers and corresponding normal mucosa were studied using gelatin zymography as well as 15 colorectal adenomas and 13 gastric cancers with corresponding normal mucosa. Overexpression of all the gelatinases occurs in both colorectal and gastric cancer, with activation of MMP-2 appearing to be a feature of the malignant phenotype. Overexpression of MMP-9 occurs in colorectal adenomas. The gelatinases are overexpressed in gastrointestinal neoplasia, suggesting that these enzymes may have an important role in tumour invasion and metastasis.

Original language	English
Pages (from-to)	1495-1502
Number of pages	8
Journal	British Journal of Cancer
Volume	78
Issue number	11
DOIs	https://doi.org/10.1038/bjc.1998.712
Publication status	Published - 1998

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adenoma
Collagenases
Colorectal Neoplasms
Gastric Mucosa
Gelatinases
Humans
Intestinal Mucosa
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Metalloendopeptidases
Neoplasm Proteins
Neoplasm Staging
Stomach Neoplasms

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10.1038/bjc.1998.712

Cite this

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title = "Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy",

abstract = "The aim of the study was to investigate expression of the active and inactive gelatinases (MMP-2 and -9) in colorectal neoplasia and gastric cancer compared with normal mucosa. A total of 53 colorectal cancers and corresponding normal mucosa were studied using gelatin zymography as well as 15 colorectal adenomas and 13 gastric cancers with corresponding normal mucosa. Overexpression of all the gelatinases occurs in both colorectal and gastric cancer, with activation of MMP-2 appearing to be a feature of the malignant phenotype. Overexpression of MMP-9 occurs in colorectal adenomas. The gelatinases are overexpressed in gastrointestinal neoplasia, suggesting that these enzymes may have an important role in tumour invasion and metastasis.",

keywords = "Adenoma, Collagenases, Colorectal Neoplasms, Gastric Mucosa, Gelatinases, Humans, Intestinal Mucosa, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Metalloendopeptidases, Neoplasm Proteins, Neoplasm Staging, Stomach Neoplasms",

author = "Parsons, \{S. L.\} and Watson, \{S. A.\} and Collins, \{H. M.\} and Griffin, \{N. R.\} and Clarke, \{P. A.\} and Steele, \{R. J. C.\}",

year = "1998",

doi = "10.1038/bjc.1998.712",

language = "English",

volume = "78",

pages = "1495--1502",

journal = "British Journal of Cancer",

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publisher = "Springer Nature",

number = "11",

}

TY - JOUR

T1 - Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy

AU - Parsons, S. L.

AU - Watson, S. A.

AU - Collins, H. M.

AU - Griffin, N. R.

AU - Clarke, P. A.

AU - Steele, R. J. C.

PY - 1998

Y1 - 1998

N2 - The aim of the study was to investigate expression of the active and inactive gelatinases (MMP-2 and -9) in colorectal neoplasia and gastric cancer compared with normal mucosa. A total of 53 colorectal cancers and corresponding normal mucosa were studied using gelatin zymography as well as 15 colorectal adenomas and 13 gastric cancers with corresponding normal mucosa. Overexpression of all the gelatinases occurs in both colorectal and gastric cancer, with activation of MMP-2 appearing to be a feature of the malignant phenotype. Overexpression of MMP-9 occurs in colorectal adenomas. The gelatinases are overexpressed in gastrointestinal neoplasia, suggesting that these enzymes may have an important role in tumour invasion and metastasis.

AB - The aim of the study was to investigate expression of the active and inactive gelatinases (MMP-2 and -9) in colorectal neoplasia and gastric cancer compared with normal mucosa. A total of 53 colorectal cancers and corresponding normal mucosa were studied using gelatin zymography as well as 15 colorectal adenomas and 13 gastric cancers with corresponding normal mucosa. Overexpression of all the gelatinases occurs in both colorectal and gastric cancer, with activation of MMP-2 appearing to be a feature of the malignant phenotype. Overexpression of MMP-9 occurs in colorectal adenomas. The gelatinases are overexpressed in gastrointestinal neoplasia, suggesting that these enzymes may have an important role in tumour invasion and metastasis.

KW - Adenoma

KW - Collagenases

KW - Colorectal Neoplasms

KW - Gastric Mucosa

KW - Gelatinases

KW - Humans

KW - Intestinal Mucosa

KW - Matrix Metalloproteinase 2

KW - Matrix Metalloproteinase 9

KW - Metalloendopeptidases

KW - Neoplasm Proteins

KW - Neoplasm Staging

KW - Stomach Neoplasms

U2 - 10.1038/bjc.1998.712

DO - 10.1038/bjc.1998.712

M3 - Article

C2 - 9836483

SN - 0007-0920

VL - 78

SP - 1495

EP - 1502

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 11

ER -

Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy

Abstract

UN SDGs

Keywords

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