Gender differences in cortical morphological networks

Ahmed Nebli, Islem Rekik (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)
175 Downloads (Pure)


Cortical morphological networks (CMN), where each network models the relationship in morphology between different cortical brain regions quantified using a specific measurement (e.g., cortical thickness), have not been investigated with respect to gender differences in the human brain. Cortical processes are expected to involve complex interactions between different brain regions, univariate methods thus might overlook informative gender markers. Hence, by leveraging machine learning techniques with the potential to highlight multivariate interacting effects, we found that the most discriminative CMN connections between males and females were derived from the left hemisphere using the mean sulcal depth as measurement. However, for both left and right hemispheres, the first most discriminative morphological connection revealed across all cortical attributes involved (entorhinal cortex ↔ caudal anterior cingulate cortex) and (entorhinal cortex ↔ transverse temporal cortex) respectively, which gives us new insights into behavioral gender differences from an omics perspective and might explain why males and females learn differently.

Original languageEnglish
Pages (from-to)1831-1839
Number of pages9
JournalBrain Imaging and Behavior
Early online date17 May 2019
Publication statusPublished - Oct 2020


  • Brain connectivity
  • Cortical morphological networks
  • Cortical morphology
  • Feature selection
  • Gender differences
  • Sulcal depth
  • T1-weighted MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience


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