Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects

Paul W. Franks; Ewan Pearson; Jose C. Florez

doi:10.2337/dc12-2211

Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects

Paul W. Franks, Ewan Pearson, Jose C. Florez

Research output: Contribution to journal › Review article › peer-review

127 Citations (Scopus)

Abstract

Type 2 diabetes has rapidly emerged as a global health crisis. Because population-level genetic changes take many generations to occur, this epidemic is almost certainly primarily a consequence of recent environmental changes; nonetheless, diabetes does appear to occur preferentially in genetically predisposed populations, which suggests that the effects of pre-existing susceptibility genes have been triggered by recent shifts in nongenetic factors.

Original language	English
Pages (from-to)	1413-1421
Number of pages	9
Journal	Diabetes Care
Volume	36
Issue number	5
DOIs	https://doi.org/10.2337/dc12-2211
Publication status	Published - May 2013

Keywords

GENOME-WIDE ASSOCIATION
FASTING GLUCOSE
INSULIN-RESISTANCE
DIETARY-FAT INTAKE
GLYCEMIC TRAITS
PHYSICAL-ACTIVITY
LIFE-STYLE INTERVENTION
BODY-MASS INDEX
IMPAIRED GLUCOSE-TOLERANCE
PREVENTION PROGRAM

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2337/dc12-2211

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title = "Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects",

abstract = "Type 2 diabetes has rapidly emerged as a global health crisis. Because population-level genetic changes take many generations to occur, this epidemic is almost certainly primarily a consequence of recent environmental changes; nonetheless, diabetes does appear to occur preferentially in genetically predisposed populations, which suggests that the effects of pre-existing susceptibility genes have been triggered by recent shifts in nongenetic factors. ",

keywords = "GENOME-WIDE ASSOCIATION, FASTING GLUCOSE, INSULIN-RESISTANCE, DIETARY-FAT INTAKE, GLYCEMIC TRAITS, PHYSICAL-ACTIVITY, LIFE-STYLE INTERVENTION, BODY-MASS INDEX, IMPAIRED GLUCOSE-TOLERANCE, PREVENTION PROGRAM",

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year = "2013",

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volume = "36",

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publisher = "American Diabetes Association Inc.",

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T1 - Gene-environment and gene-treatment interactions in type 2 diabetes

T2 - progress, pitfalls, and prospects

AU - Franks, Paul W.

AU - Pearson, Ewan

AU - Florez, Jose C.

PY - 2013/5

Y1 - 2013/5

N2 - Type 2 diabetes has rapidly emerged as a global health crisis. Because population-level genetic changes take many generations to occur, this epidemic is almost certainly primarily a consequence of recent environmental changes; nonetheless, diabetes does appear to occur preferentially in genetically predisposed populations, which suggests that the effects of pre-existing susceptibility genes have been triggered by recent shifts in nongenetic factors.

AB - Type 2 diabetes has rapidly emerged as a global health crisis. Because population-level genetic changes take many generations to occur, this epidemic is almost certainly primarily a consequence of recent environmental changes; nonetheless, diabetes does appear to occur preferentially in genetically predisposed populations, which suggests that the effects of pre-existing susceptibility genes have been triggered by recent shifts in nongenetic factors.

KW - GENOME-WIDE ASSOCIATION

KW - FASTING GLUCOSE

KW - INSULIN-RESISTANCE

KW - DIETARY-FAT INTAKE

KW - GLYCEMIC TRAITS

KW - PHYSICAL-ACTIVITY

KW - LIFE-STYLE INTERVENTION

KW - BODY-MASS INDEX

KW - IMPAIRED GLUCOSE-TOLERANCE

KW - PREVENTION PROGRAM

U2 - 10.2337/dc12-2211

DO - 10.2337/dc12-2211

M3 - Review article

C2 - 23613601

SN - 0149-5992

VL - 36

SP - 1413

EP - 1421

JO - Diabetes Care

JF - Diabetes Care

IS - 5

ER -

Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects

Abstract

Keywords

UN SDGs

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