Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects

Paul W. Franks, Ewan Pearson, Jose C. Florez

    Research output: Contribution to journalReview article

    79 Citations (Scopus)

    Abstract

    Type 2 diabetes has rapidly emerged as a global health crisis. Because population-level genetic changes take many generations to occur, this epidemic is almost certainly primarily a consequence of recent environmental changes; nonetheless, diabetes does appear to occur preferentially in genetically predisposed populations, which suggests that the effects of pre-existing susceptibility genes have been triggered by recent shifts in nongenetic factors.
    Original languageEnglish
    Pages (from-to)1413-1421
    Number of pages9
    JournalDiabetes Care
    Volume36
    Issue number5
    DOIs
    Publication statusPublished - May 2013

    Keywords

    • GENOME-WIDE ASSOCIATION
    • FASTING GLUCOSE
    • INSULIN-RESISTANCE
    • DIETARY-FAT INTAKE
    • GLYCEMIC TRAITS
    • PHYSICAL-ACTIVITY
    • LIFE-STYLE INTERVENTION
    • BODY-MASS INDEX
    • IMPAIRED GLUCOSE-TOLERANCE
    • PREVENTION PROGRAM

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