Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects

TY - JOUR

T1 - Gene-environment and gene-treatment interactions in type 2 diabetes

T2 - progress, pitfalls, and prospects

AU - Franks, Paul W.

AU - Pearson, Ewan

AU - Florez, Jose C.

PY - 2013/5

Y1 - 2013/5

N2 - Type 2 diabetes has rapidly emerged as a global health crisis. Because population-level genetic changes take many generations to occur, this epidemic is almost certainly primarily a consequence of recent environmental changes; nonetheless, diabetes does appear to occur preferentially in genetically predisposed populations, which suggests that the effects of pre-existing susceptibility genes have been triggered by recent shifts in nongenetic factors.

AB - Type 2 diabetes has rapidly emerged as a global health crisis. Because population-level genetic changes take many generations to occur, this epidemic is almost certainly primarily a consequence of recent environmental changes; nonetheless, diabetes does appear to occur preferentially in genetically predisposed populations, which suggests that the effects of pre-existing susceptibility genes have been triggered by recent shifts in nongenetic factors.

KW - GENOME-WIDE ASSOCIATION

KW - FASTING GLUCOSE

KW - INSULIN-RESISTANCE

KW - DIETARY-FAT INTAKE

KW - GLYCEMIC TRAITS

KW - PHYSICAL-ACTIVITY

KW - LIFE-STYLE INTERVENTION

KW - BODY-MASS INDEX

KW - IMPAIRED GLUCOSE-TOLERANCE

KW - PREVENTION PROGRAM

U2 - 10.2337/dc12-2211

DO - 10.2337/dc12-2211

M3 - Review article

C2 - 23613601

SN - 0149-5992

VL - 36

SP - 1413

EP - 1421

JO - Diabetes Care

JF - Diabetes Care

IS - 5

ER -