Genetic analyses of yeast protein serine/threonine phosphatases

Michael J.R. Stark, Sheila Black, Alan A. Sneddon, Paul D. Andrews

    Research output: Contribution to journalReview article

    12 Citations (Scopus)

    Abstract

    Protein phosphorylation is an important regulatory phenomenon in yeasts just as in other eukaryotic cells and controls a wide variety of cellular processes. The importance of protein phosphatases as well as protein kinases as key elements in such control is becoming increasingly clear. Over the past four years since the first yeast protein phosphatase gene was isolated, many more such genes have been described and the number of genes encoding protein phosphatase catalytic subunits in Saccharomyces cerevisiae has comfortably entered double figures. Given the genetic approaches available, yeasts offer powerful systems for addressing the cellular roles of these enzymes. This review summarises the results of genetic studies aimed at determining the functions of protein serine/threoninc phosphatases in yeast.

    Original languageEnglish
    Pages (from-to)121-130
    Number of pages10
    JournalFEMS Microbiology Letters
    Volume117
    Issue number2
    Publication statusPublished - 1 Apr 1994

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