Projects per year
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
|Number of pages||14|
|Early online date||17 Sept 2018|
|Publication status||Published - Oct 2018|
ASJC Scopus subject areas
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- 1 Finished
The Scottish eHealth Informatics Research Centre (E-HIRCs) (Joint with Universities of Aberdeen, Glasgow, Edinburgh, Strathclyde, St Andrews & Leicester and ISD)
Colhoun, H., Donnan, P., Guthrie, B., Jefferson, E., MacDonald, T., McCowan, C., Morris, A., Pearson, E., Sullivan, F. & Swedlow, J.
1/03/13 → 31/12/18
- 536 Citations
- 1 Article
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traitsMillion Veteran Program, Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., Ntritsos, G., Dimou, N., Cabrera, C. P., Karaman, I., Ng, F. L., Evangelou, M., Witkowska, K., Tzanis, E., Hellwege, J. N., Giri, A., Velez Edwards, D. R., Sun, Y. V., Cho, K., & 33 others, 14 Nov 2014, In: Nature Genetics. 50, p. 1755 1 p.
Research output: Contribution to journal › Article › peer-review
- Population Health and Genomics - Professor (Teaching and Research) of Pharmacogenomics