Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Million Veteran Program; Evangelos Evangelou; Helen R. Warren; David Mosen-Ansorena; Borbala Mifsud; Raha Pazoki; He Gao; Georgios Ntritsos; Niki Dimou; Claudia P. Cabrera; Ibrahim Karaman; Fu Liang Ng; Marina Evangelou; Katarzyna Witkowska; Evan Tzanis; Jacklyn N. Hellwege; Ayush Giri; Digna R. Velez Edwards; Yan V. Sun; Kelly Cho; J. Michael Gaziano; Peter W. F. Wilson; Philip S. Tsao; Csaba P. Kovesdy; Tonu Esko; Reedik Mägi; Lili Milani; Peter Almgren; Thibaud Boutin; Stéphanie Debette; Jun Ding; Franco Giulianini; Elizabeth G. Holliday; Anne U. Jackson; Ruifang Li-Gao; Wei-Yu Lin; Jian'an Luan; Massimo Mangino; Christopher Oldmeadow; Bram Peter Prins; Yong Qian; Muralidharan Sargurupremraj; Nabi Shah; Praveen Surendran; Sébastien Thériault; Niek Verweij; Sara M. Willems; John Connell; Andrew D. Morris; Colin N. A. Palmer; Paul Elliott; Mark J. Caulfield

doi:10.1038/s41588-018-0205-x

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Million Veteran Program, Evangelos Evangelou, Helen R. Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki, He Gao, Georgios Ntritsos, Niki Dimou, Claudia P. Cabrera, Ibrahim Karaman, Fu Liang Ng, Marina Evangelou, Katarzyna Witkowska, Evan Tzanis, Jacklyn N. Hellwege, Ayush Giri, Digna R. Velez Edwards, Yan V. Sun, Kelly ChoJ. Michael Gaziano, Peter W. F. Wilson, Philip S. Tsao, Csaba P. Kovesdy, Tonu Esko, Reedik Mägi, Lili Milani, Peter Almgren, Thibaud Boutin, Stéphanie Debette, Jun Ding, Franco Giulianini, Elizabeth G. Holliday, Anne U. Jackson, Ruifang Li-Gao, Wei-Yu Lin, Jian'an Luan, Massimo Mangino, Christopher Oldmeadow, Bram Peter Prins, Yong Qian, Muralidharan Sargurupremraj, Nabi Shah, Praveen Surendran, Sébastien Thériault, Niek Verweij, Sara M. Willems, John Connell, Andrew D. Morris, Colin N. A. Palmer, Paul Elliott, Mark J. Caulfield

Research output: Contribution to journal › Article › peer-review

325 Citations (Scopus)

Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Original language	English
Pages (from-to)	1412-1425
Number of pages	14
Journal	Nature Genetics
Volume	50
Early online date	17 Sep 2018
DOIs	https://doi.org/10.1038/s41588-018-0205-x
Publication status	Published - Oct 2018

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Million Veteran Program, Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., Ntritsos, G., Dimou, N., Cabrera, C. P., Karaman, I., Ng, F. L., Evangelou, M., Witkowska, K., Tzanis, E., Hellwege, J. N., Giri, A., Velez Edwards, D. R., Sun, Y. V., ... Caulfield, M. J. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50, 1412-1425. https://doi.org/10.1038/s41588-018-0205-x

Million Veteran Program ; Evangelou, Evangelos ; Warren, Helen R. ; Mosen-Ansorena, David ; Mifsud, Borbala ; Pazoki, Raha ; Gao, He ; Ntritsos, Georgios ; Dimou, Niki ; Cabrera, Claudia P. ; Karaman, Ibrahim ; Ng, Fu Liang ; Evangelou, Marina ; Witkowska, Katarzyna ; Tzanis, Evan ; Hellwege, Jacklyn N. ; Giri, Ayush ; Velez Edwards, Digna R. ; Sun, Yan V. ; Cho, Kelly ; Gaziano, J. Michael ; Wilson, Peter W. F. ; Tsao, Philip S. ; Kovesdy, Csaba P. ; Esko, Tonu ; Mägi, Reedik ; Milani, Lili ; Almgren, Peter ; Boutin, Thibaud ; Debette, Stéphanie ; Ding, Jun ; Giulianini, Franco ; Holliday, Elizabeth G. ; Jackson, Anne U. ; Li-Gao, Ruifang ; Lin, Wei-Yu ; Luan, Jian'an ; Mangino, Massimo ; Oldmeadow, Christopher ; Prins, Bram Peter ; Qian, Yong ; Sargurupremraj, Muralidharan ; Shah, Nabi ; Surendran, Praveen ; Thériault, Sébastien ; Verweij, Niek ; Willems, Sara M. ; Connell, John ; Morris, Andrew D. ; Palmer, Colin N. A. ; Elliott, Paul ; Caulfield, Mark J. / Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. In: Nature Genetics. 2018 ; Vol. 50. pp. 1412-1425.

@article{c4655c0c2bc9475490e9576766d9e888,

title = "Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits",

abstract = "High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.",

author = "{Million Veteran Program} and Evangelos Evangelou and Warren, {Helen R.} and David Mosen-Ansorena and Borbala Mifsud and Raha Pazoki and He Gao and Georgios Ntritsos and Niki Dimou and Cabrera, {Claudia P.} and Ibrahim Karaman and Ng, {Fu Liang} and Marina Evangelou and Katarzyna Witkowska and Evan Tzanis and Hellwege, {Jacklyn N.} and Ayush Giri and {Velez Edwards}, {Digna R.} and Sun, {Yan V.} and Kelly Cho and Gaziano, {J. Michael} and Wilson, {Peter W. F.} and Tsao, {Philip S.} and Kovesdy, {Csaba P.} and Tonu Esko and Reedik M{\"a}gi and Lili Milani and Peter Almgren and Thibaud Boutin and St{\'e}phanie Debette and Jun Ding and Franco Giulianini and Holliday, {Elizabeth G.} and Jackson, {Anne U.} and Ruifang Li-Gao and Wei-Yu Lin and Jian'an Luan and Massimo Mangino and Christopher Oldmeadow and Prins, {Bram Peter} and Yong Qian and Muralidharan Sargurupremraj and Nabi Shah and Praveen Surendran and S{\'e}bastien Th{\'e}riault and Niek Verweij and Willems, {Sara M.} and John Connell and Morris, {Andrew D.} and Palmer, {Colin N. A.} and Paul Elliott and Caulfield, {Mark J.}",

year = "2018",

month = oct,

doi = "10.1038/s41588-018-0205-x",

language = "English",

volume = "50",

pages = "1412--1425",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

}

Million Veteran Program, Evangelou, E, Warren, HR, Mosen-Ansorena, D, Mifsud, B, Pazoki, R, Gao, H, Ntritsos, G, Dimou, N, Cabrera, CP, Karaman, I, Ng, FL, Evangelou, M, Witkowska, K, Tzanis, E, Hellwege, JN, Giri, A, Velez Edwards, DR, Sun, YV, Cho, K, Gaziano, JM, Wilson, PWF, Tsao, PS, Kovesdy, CP, Esko, T, Mägi, R, Milani, L, Almgren, P, Boutin, T, Debette, S, Ding, J, Giulianini, F, Holliday, EG, Jackson, AU, Li-Gao, R, Lin, W-Y, Luan, J, Mangino, M, Oldmeadow, C, Prins, BP, Qian, Y, Sargurupremraj, M, Shah, N, Surendran, P, Thériault, S, Verweij, N, Willems, SM, Connell, J, Morris, AD, Palmer, CNA, Elliott, P & Caulfield, MJ 2018, 'Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits', Nature Genetics, vol. 50, pp. 1412-1425. https://doi.org/10.1038/s41588-018-0205-x

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. / Million Veteran Program; Evangelou, Evangelos; Warren, Helen R.; Mosen-Ansorena, David; Mifsud, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrera, Claudia P.; Karaman, Ibrahim; Ng, Fu Liang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N.; Giri, Ayush; Velez Edwards, Digna R.; Sun, Yan V.; Cho, Kelly; Gaziano, J. Michael; Wilson, Peter W. F.; Tsao, Philip S.; Kovesdy, Csaba P.; Esko, Tonu; Mägi, Reedik; Milani, Lili; Almgren, Peter; Boutin, Thibaud; Debette, Stéphanie; Ding, Jun; Giulianini, Franco; Holliday, Elizabeth G.; Jackson, Anne U.; Li-Gao, Ruifang; Lin, Wei-Yu; Luan, Jian'an; Mangino, Massimo; Oldmeadow, Christopher; Prins, Bram Peter; Qian, Yong; Sargurupremraj, Muralidharan; Shah, Nabi; Surendran, Praveen; Thériault, Sébastien; Verweij, Niek; Willems, Sara M.; Connell, John; Morris, Andrew D.; Palmer, Colin N. A.; Elliott, Paul (Lead / Corresponding author); Caulfield, Mark J. (Lead / Corresponding author).

In: Nature Genetics, Vol. 50, 10.2018, p. 1412-1425.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

AU - Million Veteran Program

AU - Evangelou, Evangelos

AU - Warren, Helen R.

AU - Mosen-Ansorena, David

AU - Mifsud, Borbala

AU - Pazoki, Raha

AU - Gao, He

AU - Ntritsos, Georgios

AU - Dimou, Niki

AU - Cabrera, Claudia P.

AU - Karaman, Ibrahim

AU - Ng, Fu Liang

AU - Evangelou, Marina

AU - Witkowska, Katarzyna

AU - Tzanis, Evan

AU - Hellwege, Jacklyn N.

AU - Giri, Ayush

AU - Velez Edwards, Digna R.

AU - Sun, Yan V.

AU - Cho, Kelly

AU - Gaziano, J. Michael

AU - Wilson, Peter W. F.

AU - Tsao, Philip S.

AU - Kovesdy, Csaba P.

AU - Esko, Tonu

AU - Mägi, Reedik

AU - Milani, Lili

AU - Almgren, Peter

AU - Boutin, Thibaud

AU - Debette, Stéphanie

AU - Ding, Jun

AU - Giulianini, Franco

AU - Holliday, Elizabeth G.

AU - Jackson, Anne U.

AU - Li-Gao, Ruifang

AU - Lin, Wei-Yu

AU - Luan, Jian'an

AU - Mangino, Massimo

AU - Oldmeadow, Christopher

AU - Prins, Bram Peter

AU - Qian, Yong

AU - Sargurupremraj, Muralidharan

AU - Shah, Nabi

AU - Surendran, Praveen

AU - Thériault, Sébastien

AU - Verweij, Niek

AU - Willems, Sara M.

AU - Connell, John

AU - Morris, Andrew D.

AU - Palmer, Colin N. A.

AU - Elliott, Paul

AU - Caulfield, Mark J.

PY - 2018/10

Y1 - 2018/10

N2 - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

AB - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

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UR - http://europepmc.org/articles/PMC6284793?fromSearch=singleResult&fromQuery=30224653

U2 - 10.1038/s41588-018-0205-x

DO - 10.1038/s41588-018-0205-x

M3 - Article

C2 - 30224653

VL - 50

SP - 1412

EP - 1425

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

ER -

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

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Palmer, Colin

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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Abstract

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Palmer, Colin

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