Genetic and environmental determinants of surface adaptations in Pseudomonas aeruginosa

Sakthivel Ambreetha, Varsha Singh (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)
16 Downloads (Pure)

Abstract

Pseudomonas aeruginosa is a well-studied Gram-negative opportunistic bacterium that thrives in markedly varied environ-ments. It is a nutritionally versatile microbe that can colonize a host as well as exist in the environment. Unicellular, planktonic cells of P. aeruginosa can come together to perform a coordinated swarming movement or turn into a sessile, surface-adhered population called biofilm. These collective behaviours produce strikingly different outcomes. While swarming motility rapidly disseminates the bacterial population, biofilm collectively protects the population from environmental stresses such as heat, drought, toxic chemicals, grazing by predators, and attack by host immune cells and antibiotics. The ubiquitous nature of P. aeruginosa is likely to be supported by the timely transition between planktonic, swarming and biofilm lifestyles. The social behaviours of this bacteria viz biofilm and swarm modes are controlled by signals from quorum-sensing networks, LasI-LasR, RhlI-RhlR and PQS-MvfR, and several other sensory kinases and response regulators. A combination of environmental and genetic cues regulates the transition of the P. aeruginosa population to specific states. The current review is aimed at discussing key factors that promote physiologically distinct transitioning of the P. aeruginosa population.

Original languageEnglish
Article number001335
JournalMicrobiology (United Kingdom)
Volume169
Issue number6
DOIs
Publication statusPublished - 5 Jun 2023

Keywords

  • biofilm
  • environmental signals
  • Pseudomonas aeruginosa
  • quorum sensing
  • response regulators
  • sensor kinases
  • swarming motility

ASJC Scopus subject areas

  • Microbiology

Fingerprint

Dive into the research topics of 'Genetic and environmental determinants of surface adaptations in Pseudomonas aeruginosa'. Together they form a unique fingerprint.

Cite this