Genetic correlations between pain phenotypes and depression and neuroticism

Weihua Meng (Lead / Corresponding author), Mark J. Adams, Parminder Reel, Aravind Rajendrakumar, Yu Huang, Ian J. Deary, Colin N. A. Palmer, Andrew M. McIntosh, Blair H. Smith

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Abstract

Correlations between pain phenotypes and psychiatric traits such as depression and the personality trait of neuroticism are not fully understood. In this study, we estimated the genetic correlations of eight pain phenotypes (defined by the UK Biobank, n = 151,922–226,683) with depressive symptoms, major depressive disorders and neuroticism using the the cross-trait linkage disequilibrium score regression (LDSC) method integrated in the LD Hub. We also used the LDSC software to calculate the genetic correlations among pain phenotypes. All pain phenotypes, except hip pain and knee pain, had significant and positive genetic correlations with depressive symptoms, major depressive disorders and neuroticism. All pain phenotypes were heritable, with pain all over the body showing the highest heritability (h 2 = 0.31, standard error = 0.072). Many pain phenotypes had positive and significant genetic correlations with each other indicating shared genetic mechanisms. Our results suggest that pain, neuroticism and depression share partially overlapping genetic risk factors.

Original languageEnglish
Number of pages9
JournalEuropean Journal of Human Genetics
Early online date29 Oct 2019
DOIs
Publication statusE-pub ahead of print - 29 Oct 2019

Fingerprint

Depression
Phenotype
Pain
Linkage Disequilibrium
Major Depressive Disorder
Neuroticism
Psychiatry
Personality
Hip
Knee
Software

Keywords

  • Genetic correlation
  • pain
  • genome-wide association study
  • UK Biobank
  • depression
  • neuroticism

Cite this

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title = "Genetic correlations between pain phenotypes and depression and neuroticism",
abstract = "Correlations between pain phenotypes and psychiatric traits such as depression and the personality trait of neuroticism are not fully understood. In this study, we estimated the genetic correlations of eight pain phenotypes (defined by the UK Biobank, n = 151,922–226,683) with depressive symptoms, major depressive disorders and neuroticism using the the cross-trait linkage disequilibrium score regression (LDSC) method integrated in the LD Hub. We also used the LDSC software to calculate the genetic correlations among pain phenotypes. All pain phenotypes, except hip pain and knee pain, had significant and positive genetic correlations with depressive symptoms, major depressive disorders and neuroticism. All pain phenotypes were heritable, with pain all over the body showing the highest heritability (h 2 = 0.31, standard error = 0.072). Many pain phenotypes had positive and significant genetic correlations with each other indicating shared genetic mechanisms. Our results suggest that pain, neuroticism and depression share partially overlapping genetic risk factors.",
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note = "This work was supported by the STRADL project [Wellcome Trust, grant number: 104036/Z/14/Z], and the Centre for Cognitive Ageing and Cognitive Epidemiology [Medical Research Council and Biotechnology and Biological Sciences Research Council, grant number: MR/K026992/1]. We are grateful for support from the Sackler Foundation.",
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AU - Adams, Mark J.

AU - Reel, Parminder

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AU - Deary, Ian J.

AU - Palmer, Colin N. A.

AU - McIntosh, Andrew M.

AU - Smith, Blair H.

N1 - This work was supported by the STRADL project [Wellcome Trust, grant number: 104036/Z/14/Z], and the Centre for Cognitive Ageing and Cognitive Epidemiology [Medical Research Council and Biotechnology and Biological Sciences Research Council, grant number: MR/K026992/1]. We are grateful for support from the Sackler Foundation.

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N2 - Correlations between pain phenotypes and psychiatric traits such as depression and the personality trait of neuroticism are not fully understood. In this study, we estimated the genetic correlations of eight pain phenotypes (defined by the UK Biobank, n = 151,922–226,683) with depressive symptoms, major depressive disorders and neuroticism using the the cross-trait linkage disequilibrium score regression (LDSC) method integrated in the LD Hub. We also used the LDSC software to calculate the genetic correlations among pain phenotypes. All pain phenotypes, except hip pain and knee pain, had significant and positive genetic correlations with depressive symptoms, major depressive disorders and neuroticism. All pain phenotypes were heritable, with pain all over the body showing the highest heritability (h 2 = 0.31, standard error = 0.072). Many pain phenotypes had positive and significant genetic correlations with each other indicating shared genetic mechanisms. Our results suggest that pain, neuroticism and depression share partially overlapping genetic risk factors.

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