Genetic determinants of delayed graft function after kidney transplantation

Shawn D. St. Peter, Charles J. Imber, Des C. Jones, Susan V. Fuggle, Christopher J. Watson, Peter J. Friend, Sara E. Marshall

    Research output: Contribution to journalArticlepeer-review

    22 Citations (Scopus)

    Abstract

    Background. Intracellular concentration of reactive oxygen species is held within tight physiological limits by enzymes with scavenging and repair functions. Under extreme conditions such as prolonged cold ischemia, these enzymes may be unable to adequately protect the organ, resulting in reperfusion injury that renders the graft dysfunctional after transplantation. In this study, we investigated normal human variation of some of these inducible enzymes to determine if certain phenotypes could be identified that are associated with a reduced risk of delayed graft function (DGF).
    Original languageEnglish
    Pages (from-to)809-813
    Number of pages5
    JournalTransplantation
    Volume74
    Issue number6
    DOIs
    Publication statusPublished - 2002

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