Genetic determinants of delayed graft function after kidney transplantation

Shawn D. St. Peter; Charles J. Imber; Des C. Jones; Susan V. Fuggle; Christopher J. Watson; Peter J. Friend; Sara E. Marshall

doi:10.1097/00007890-200209270-00013

Genetic determinants of delayed graft function after kidney transplantation

Shawn D. St. Peter, Charles J. Imber, Des C. Jones, Susan V. Fuggle, Christopher J. Watson, Peter J. Friend, Sara E. Marshall

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Background. Intracellular concentration of reactive oxygen species is held within tight physiological limits by enzymes with scavenging and repair functions. Under extreme conditions such as prolonged cold ischemia, these enzymes may be unable to adequately protect the organ, resulting in reperfusion injury that renders the graft dysfunctional after transplantation. In this study, we investigated normal human variation of some of these inducible enzymes to determine if certain phenotypes could be identified that are associated with a reduced risk of delayed graft function (DGF).

Original language	English
Pages (from-to)	809-813
Number of pages	5
Journal	Transplantation
Volume	74
Issue number	6
DOIs	https://doi.org/10.1097/00007890-200209270-00013
Publication status	Published - 2002

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title = "Genetic determinants of delayed graft function after kidney transplantation",

abstract = "Background. Intracellular concentration of reactive oxygen species is held within tight physiological limits by enzymes with scavenging and repair functions. Under extreme conditions such as prolonged cold ischemia, these enzymes may be unable to adequately protect the organ, resulting in reperfusion injury that renders the graft dysfunctional after transplantation. In this study, we investigated normal human variation of some of these inducible enzymes to determine if certain phenotypes could be identified that are associated with a reduced risk of delayed graft function (DGF).",

author = "{St. Peter}, {Shawn D.} and Imber, {Charles J.} and Jones, {Des C.} and Fuggle, {Susan V.} and Watson, {Christopher J.} and Friend, {Peter J.} and Marshall, {Sara E.}",

note = "dc.publisher: Lippincott, Williams & Wilkins dc.description.sponsorship: S.E.M.is funded by a Clinician Scientist Fellowship from the Medical Research Council, UK, C.I. is funded by the Hanson trust. ",

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doi = "10.1097/00007890-200209270-00013",

language = "English",

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TY - JOUR

T1 - Genetic determinants of delayed graft function after kidney transplantation

AU - St. Peter, Shawn D.

AU - Imber, Charles J.

AU - Jones, Des C.

AU - Fuggle, Susan V.

AU - Watson, Christopher J.

AU - Friend, Peter J.

AU - Marshall, Sara E.

N1 - dc.publisher: Lippincott, Williams & Wilkins dc.description.sponsorship: S.E.M.is funded by a Clinician Scientist Fellowship from the Medical Research Council, UK, C.I. is funded by the Hanson trust.

PY - 2002

Y1 - 2002

N2 - Background. Intracellular concentration of reactive oxygen species is held within tight physiological limits by enzymes with scavenging and repair functions. Under extreme conditions such as prolonged cold ischemia, these enzymes may be unable to adequately protect the organ, resulting in reperfusion injury that renders the graft dysfunctional after transplantation. In this study, we investigated normal human variation of some of these inducible enzymes to determine if certain phenotypes could be identified that are associated with a reduced risk of delayed graft function (DGF).

AB - Background. Intracellular concentration of reactive oxygen species is held within tight physiological limits by enzymes with scavenging and repair functions. Under extreme conditions such as prolonged cold ischemia, these enzymes may be unable to adequately protect the organ, resulting in reperfusion injury that renders the graft dysfunctional after transplantation. In this study, we investigated normal human variation of some of these inducible enzymes to determine if certain phenotypes could be identified that are associated with a reduced risk of delayed graft function (DGF).

U2 - 10.1097/00007890-200209270-00013

DO - 10.1097/00007890-200209270-00013

M3 - Article

SN - 0041-1337

VL - 74

SP - 809

EP - 813

JO - Transplantation

JF - Transplantation

IS - 6

ER -

Genetic determinants of delayed graft function after kidney transplantation

Abstract

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