Genetic loci influencing kidney function and chronic kidney disease

John C. Chambers, Weihua Zhang, Graham M. Lord, Pim van der Harst, Debbie A. Lawlor, Joban S. Sehmi, Daniel P. Gale, Mark N. Wass, Kourosh R. Ahmadi, Stephan J. L. Bakker, Jacqui Beckmann, Henk J. G. Bilo, Murielle Bochud, Morris J. Brown, Mark J. Caulfield, John M. C. Connell, H. Terence Cook, Ioana Cotlarciuc, George Davey Smith, Ranil de SilvaGuohong Deng, Olivier Devuyst, Lambert D. Dikkeschei, Nada Dimkovic, Mark Dockrell, Anna Dominiczak, Shah Ebrahim, Thomas Eggermann, Martin Farrall, Luigi Ferrucci, Jurgen Floege, Nita G. Forouhi, Ron T. Gansevoort, Xijin Han, Bo Hedblad, Jaap J. Homan van der Heide, Bouke G. Hepkema, Maria Hernandez-Fuentes, Elina Hypponen, Toby Johnson, Paul E. de Jong, Nanne Kleefstra, Vasiliki Lagou, Marta Lapsley, Yun Li, Ruth J. F. Loos, Jian'an Luan, Karin Luttropp, Celine Marechal, Olle Melander, Patricia B. Munroe, Louise Nordfors, Afshin Parsa, Leena Peltonen, Brenda W. Penninx, Esperanza Perucha, Anneli Pouta, Inga Prokopenko, Paul J. Roderick, Aimo Ruokonen, Nilesh J. Samani, Serena Sanna, Martin Schalling, David Schlessinger, Georg Schlieper, Marc A. J. Seelen, Alan R. Shuldiner, Marketa Sjogren, Johannes H. Smit, Harold Snieder, Nicole Soranzo, Timothy D. Spector, Peter Stenvinkel, Michael J. E. Sternberg, Ramasamyiyer Swaminathan, Toshiko Tanaka, Lielith J. Ubink-Veltmaat, Manuela Uda, Peter Vollenweider, Chris Wallace, Dawn Waterworth, Klaus Zerres, Gerard Waeber, Nicholas J. Wareham, Patrick H. Maxwell, Mark I. McCarthy, Marjo-Riitta Jarvelin, Vincent Mooser, Goncalo R. Abecasis, Liz Lightstone, James Scott, Gerjan Navis, Paul Elliott, Jaspal S. Kooner

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    Abstract

    Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

    Original languageEnglish
    Pages (from-to)373-375
    Number of pages3
    JournalNature Genetics
    Volume42
    Issue number5
    DOIs
    Publication statusPublished - May 2010

    Cite this

    Chambers, J. C., Zhang, W., Lord, G. M., van der Harst, P., Lawlor, D. A., Sehmi, J. S., Gale, D. P., Wass, M. N., Ahmadi, K. R., Bakker, S. J. L., Beckmann, J., Bilo, H. J. G., Bochud, M., Brown, M. J., Caulfield, M. J., Connell, J. M. C., Cook, H. T., Cotlarciuc, I., Smith, G. D., ... Kooner, J. S. (2010). Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics, 42(5), 373-375. https://doi.org/10.1038/ng.566