Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats

Surasak Kantachuvesiri; Chris S. Haley; Stewart Fleming; Katarna Kurian; Caroline E. Whitworth; Philip Wenham; Yuri Kotelevtsev; John J. Mullins

doi:10.1046/j.1523-1755.1999.00571.x

Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats

Surasak Kantachuvesiri, Chris S. Haley, Stewart Fleming, Katarna Kurian, Caroline E. Whitworth, Philip Wenham, Yuri Kotelevtsev, John J. Mullins

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Genetic background has a major influence on the manifestation of multifactorial diseases such as hypertension in which severe complications may be caused through an interaction with additional factors, which may be genetically determined. We have previously described a genetic model of malignant hypertension (MH) in rats carrying the mouse Ren2 gene (TGRmRen2-27), in which the phenotype is dependent on the genetic background.

Original language	English
Pages (from-to)	414-20
Number of pages	7
Journal	Kidney International
Volume	56
Issue number	2
DOIs	https://doi.org/10.1046/j.1523-1755.1999.00571.x
Publication status	Published - 1999

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title = "Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats",

abstract = "Genetic background has a major influence on the manifestation of multifactorial diseases such as hypertension in which severe complications may be caused through an interaction with additional factors, which may be genetically determined. We have previously described a genetic model of malignant hypertension (MH) in rats carrying the mouse Ren2 gene (TGRmRen2-27), in which the phenotype is dependent on the genetic background.",

author = "Surasak Kantachuvesiri and Haley, {Chris S.} and Stewart Fleming and Katarna Kurian and Whitworth, {Caroline E.} and Philip Wenham and Yuri Kotelevtsev and Mullins, {John J.}",

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AU - Kantachuvesiri, Surasak

AU - Haley, Chris S.

AU - Fleming, Stewart

AU - Kurian, Katarna

AU - Whitworth, Caroline E.

AU - Wenham, Philip

AU - Kotelevtsev, Yuri

AU - Mullins, John J.

PY - 1999

Y1 - 1999

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AB - Genetic background has a major influence on the manifestation of multifactorial diseases such as hypertension in which severe complications may be caused through an interaction with additional factors, which may be genetically determined. We have previously described a genetic model of malignant hypertension (MH) in rats carrying the mouse Ren2 gene (TGRmRen2-27), in which the phenotype is dependent on the genetic background.

U2 - 10.1046/j.1523-1755.1999.00571.x

DO - 10.1046/j.1523-1755.1999.00571.x

M3 - Article

C2 - 10432379

SN - 0085-2538

VL - 56

SP - 414

EP - 420

JO - Kidney International

JF - Kidney International

IS - 2

ER -

Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats

Abstract

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