TY - JOUR
T1 - Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats
AU - Kantachuvesiri, Surasak
AU - Haley, Chris S.
AU - Fleming, Stewart
AU - Kurian, Katarna
AU - Whitworth, Caroline E.
AU - Wenham, Philip
AU - Kotelevtsev, Yuri
AU - Mullins, John J.
PY - 1999
Y1 - 1999
N2 - Genetic background has a major influence on the manifestation of multifactorial diseases such as hypertension in which severe complications may be caused through an interaction with additional factors, which may be genetically determined. We have previously described a genetic model of malignant hypertension (MH) in rats carrying the mouse Ren2 gene (TGRmRen2-27), in which the phenotype is dependent on the genetic background.
AB - Genetic background has a major influence on the manifestation of multifactorial diseases such as hypertension in which severe complications may be caused through an interaction with additional factors, which may be genetically determined. We have previously described a genetic model of malignant hypertension (MH) in rats carrying the mouse Ren2 gene (TGRmRen2-27), in which the phenotype is dependent on the genetic background.
U2 - 10.1046/j.1523-1755.1999.00571.x
DO - 10.1046/j.1523-1755.1999.00571.x
M3 - Article
C2 - 10432379
SN - 0085-2538
VL - 56
SP - 414
EP - 420
JO - Kidney International
JF - Kidney International
IS - 2
ER -