Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats

Surasak Kantachuvesiri, Chris S. Haley, Stewart Fleming, Katarna Kurian, Caroline E. Whitworth, Philip Wenham, Yuri Kotelevtsev, John J. Mullins

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    39 Citations (Scopus)

    Abstract

    Genetic background has a major influence on the manifestation of multifactorial diseases such as hypertension in which severe complications may be caused through an interaction with additional factors, which may be genetically determined. We have previously described a genetic model of malignant hypertension (MH) in rats carrying the mouse Ren2 gene (TGRmRen2-27), in which the phenotype is dependent on the genetic background.
    Original languageEnglish
    Pages (from-to)414-20
    Number of pages7
    JournalKidney International
    Volume56
    Issue number2
    DOIs
    Publication statusPublished - 1999

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    Kantachuvesiri, S., Haley, C. S., Fleming, S., Kurian, K., Whitworth, C. E., Wenham, P., Kotelevtsev, Y., & Mullins, J. J. (1999). Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats. Kidney International, 56(2), 414-20. https://doi.org/10.1046/j.1523-1755.1999.00571.x