Genetic background has a major influence on the manifestation of multifactorial diseases such as hypertension in which severe complications may be caused through an interaction with additional factors, which may be genetically determined. We have previously described a genetic model of malignant hypertension (MH) in rats carrying the mouse Ren2 gene (TGRmRen2-27), in which the phenotype is dependent on the genetic background.
Kantachuvesiri, S., Haley, C. S., Fleming, S., Kurian, K., Whitworth, C. E., Wenham, P., Kotelevtsev, Y., & Mullins, J. J. (1999). Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats. Kidney International, 56(2), 414-20. https://doi.org/10.1046/j.1523-1755.1999.00571.x