Genetic polymorphism of cytochrome P450 2C19 in healthy Malaysian subjects

Y S Yang, L P Wong, T C Lee, A M Mustafa, Z Mohamed, Chim C Lang

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Abstract

    Impaired S-mephenytoin 4'-hydroxylation is a well-described genetic polymorphism affecting drug metabolism in humans. Although ethnic differences in its distribution of polymorphism has been described, it is not known whether there is an ethnic heterogeneity of the structure and expression of the CYP2C19 enzyme in the Malaysian population.
    Original languageEnglish
    Pages (from-to)332-5
    Number of pages4
    JournalBritish Journal of Clinical Pharmacology
    Volume58
    Issue number3
    DOIs
    Publication statusPublished - 2004

    Fingerprint

    Mephenytoin
    Genetic Polymorphisms
    Hydroxylation
    Cytochrome P-450 Enzyme System
    Healthy Volunteers
    Enzymes
    Pharmaceutical Preparations
    Population
    Cytochrome P-450 CYP2C19

    Cite this

    Yang, Y S ; Wong, L P ; Lee, T C ; Mustafa, A M ; Mohamed, Z ; Lang, Chim C. / Genetic polymorphism of cytochrome P450 2C19 in healthy Malaysian subjects. In: British Journal of Clinical Pharmacology. 2004 ; Vol. 58, No. 3. pp. 332-5.
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    author = "Yang, {Y S} and Wong, {L P} and Lee, {T C} and Mustafa, {A M} and Z Mohamed and Lang, {Chim C}",
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    Genetic polymorphism of cytochrome P450 2C19 in healthy Malaysian subjects. / Yang, Y S ; Wong, L P; Lee, T C ; Mustafa, A M; Mohamed, Z; Lang, Chim C.

    In: British Journal of Clinical Pharmacology, Vol. 58, No. 3, 2004, p. 332-5.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Genetic polymorphism of cytochrome P450 2C19 in healthy Malaysian subjects

    AU - Yang, Y S

    AU - Wong, L P

    AU - Lee, T C

    AU - Mustafa, A M

    AU - Mohamed, Z

    AU - Lang, Chim C

    PY - 2004

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    AB - Impaired S-mephenytoin 4'-hydroxylation is a well-described genetic polymorphism affecting drug metabolism in humans. Although ethnic differences in its distribution of polymorphism has been described, it is not known whether there is an ethnic heterogeneity of the structure and expression of the CYP2C19 enzyme in the Malaysian population.

    U2 - 10.1111/j.1365-2125.2004.02144.x

    DO - 10.1111/j.1365-2125.2004.02144.x

    M3 - Article

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    JO - British Journal of Clinical Pharmacology

    JF - British Journal of Clinical Pharmacology

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