Genetic polymorphism of cytochrome P450 2C19 in healthy Malaysian subjects

Y S  Yang; L P Wong; T C  Lee; A M Mustafa; Z Mohamed; Chim C Lang

doi:10.1111/j.1365-2125.2004.02144.x

Genetic polymorphism of cytochrome P450 2C19 in healthy Malaysian subjects

Y S Yang, L P Wong, T C Lee, A M Mustafa, Z Mohamed, Chim C Lang

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53 Citations (Scopus)

Abstract

Impaired S-mephenytoin 4'-hydroxylation is a well-described genetic polymorphism affecting drug metabolism in humans. Although ethnic differences in its distribution of polymorphism has been described, it is not known whether there is an ethnic heterogeneity of the structure and expression of the CYP2C19 enzyme in the Malaysian population.

Original language	English
Pages (from-to)	332-5
Number of pages	4
Journal	British Journal of Clinical Pharmacology
Volume	58
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2125.2004.02144.x
Publication status	Published - 2004

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10.1111/j.1365-2125.2004.02144.x

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title = "Genetic polymorphism of cytochrome P450 2C19 in healthy Malaysian subjects",

abstract = "Impaired S-mephenytoin 4'-hydroxylation is a well-described genetic polymorphism affecting drug metabolism in humans. Although ethnic differences in its distribution of polymorphism has been described, it is not known whether there is an ethnic heterogeneity of the structure and expression of the CYP2C19 enzyme in the Malaysian population.",

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AU - Wong, L P

AU - Lee, T C

AU - Mustafa, A M

AU - Mohamed, Z

AU - Lang, Chim C

PY - 2004

Y1 - 2004

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AB - Impaired S-mephenytoin 4'-hydroxylation is a well-described genetic polymorphism affecting drug metabolism in humans. Although ethnic differences in its distribution of polymorphism has been described, it is not known whether there is an ethnic heterogeneity of the structure and expression of the CYP2C19 enzyme in the Malaysian population.

U2 - 10.1111/j.1365-2125.2004.02144.x

DO - 10.1111/j.1365-2125.2004.02144.x

M3 - Article

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SP - 332

EP - 335

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 3

ER -

Genetic polymorphism of cytochrome P450 2C19 in healthy Malaysian subjects

Abstract

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