Genetic polymorphism of cytochrome P450 2C19 in healthy Malaysian subjects

Y S Yang, L P Wong, T C Lee, A M Mustafa, Z Mohamed, Chim C Lang

    Research output: Contribution to journalArticle

    45 Citations (Scopus)

    Abstract

    Impaired S-mephenytoin 4'-hydroxylation is a well-described genetic polymorphism affecting drug metabolism in humans. Although ethnic differences in its distribution of polymorphism has been described, it is not known whether there is an ethnic heterogeneity of the structure and expression of the CYP2C19 enzyme in the Malaysian population.
    Original languageEnglish
    Pages (from-to)332-5
    Number of pages4
    JournalBritish Journal of Clinical Pharmacology
    Volume58
    Issue number3
    DOIs
    Publication statusPublished - 2004

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