Genetic polymorphism of cytochrome P450 2C19 in healthy Malaysian subjects

TY - JOUR

T1 - Genetic polymorphism of cytochrome P450 2C19 in healthy Malaysian subjects

AU - Yang, Y S

AU - Wong, L P

AU - Lee, T C

AU - Mustafa, A M

AU - Mohamed, Z

AU - Lang, Chim C

PY - 2004

Y1 - 2004

N2 - Impaired S-mephenytoin 4'-hydroxylation is a well-described genetic polymorphism affecting drug metabolism in humans. Although ethnic differences in its distribution of polymorphism has been described, it is not known whether there is an ethnic heterogeneity of the structure and expression of the CYP2C19 enzyme in the Malaysian population.

AB - Impaired S-mephenytoin 4'-hydroxylation is a well-described genetic polymorphism affecting drug metabolism in humans. Although ethnic differences in its distribution of polymorphism has been described, it is not known whether there is an ethnic heterogeneity of the structure and expression of the CYP2C19 enzyme in the Malaysian population.

U2 - 10.1111/j.1365-2125.2004.02144.x

DO - 10.1111/j.1365-2125.2004.02144.x

M3 - Article

C2 - 15327595

SN - 0306-5251

VL - 58

SP - 332

EP - 335

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 3

ER -