Genetic profiling versus drug rotation in the optimisation of antihypertensive treatment

Isla S. Mackenzie, Morris J. Brown

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    There is a greater choice of drug classes for hypertension than most other diseases, increasing paradoxically the difficulty of finding the right drug for individual patients. Systematic drug rotation studies have shown that the rank order of response to different drugs varies substantially among patients. However, two broad patterns of response emerge, named after the initials of the major drug classes. The AB pattern is seen in Type 1 (high-renin) hypertensives. These are younger Caucasians who respond best to angiotensin-converting enzyme (ACE) inhibitors, angiotensin blockers and β-blockers. The CD pattern is seen in Type 2 (low-renin) patients. These are Afro-Caribbeans and older Caucasians, who respond best to calcium blockers and diuretics. This relative homogeneity of phenotype at each age group contrasts with a large heterogeneity of genotype on recent genomewide scans, and suggests that most hypertension is due to interaction among multiple minor genetic variants. Genotype is unlikely therefore to be useful in selecting treatment for most patients. The exception is patients who have the atypical phenotype for their age, illustrated by the rare Na+ dependent monogenic syndromes of the young.

    Original languageEnglish
    Pages (from-to)465-473
    Number of pages9
    JournalClinical Medicine
    Volume2
    Issue number5
    DOIs
    Publication statusPublished - Sept 2002

    Keywords

    • Aldosterone
    • Cross-over study
    • Hypertension
    • Pharmacogenetics
    • Spironolactone

    ASJC Scopus subject areas

    • General Medicine

    Fingerprint

    Dive into the research topics of 'Genetic profiling versus drug rotation in the optimisation of antihypertensive treatment'. Together they form a unique fingerprint.

    Cite this