Genetically Humanized Animal Models

K. Samuelsson, N. Scheer, I. Wilson, C Wolf, Colin J Henderson

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.
    Original languageEnglish
    Title of host publicationComprehensive Medicinal Chemistry III
    EditorsSamuel Chackalamannil, David P. Rotella, Simon E. Ward
    PublisherElsevier
    Pages130-149
    Number of pages20
    ISBN (Electronic)9780128032015
    ISBN (Print)9780128032008
    DOIs
    Publication statusE-pub ahead of print - 13 Jun 2017

    Publication series

    NameReference Module in Chemistry, Molecular Sciences and Chemical Engineering
    PublisherElsevier

    Keywords

    • Chimeric liver-humanized mice
    • Drug distribution
    • Drug metabolism
    • Genetically humanized mice
    • Knockout mice
    • Toxicology

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  • Cite this

    Samuelsson, K., Scheer, N., Wilson, I., Wolf, C., & Henderson, C. J. (2017). Genetically Humanized Animal Models. In S. Chackalamannil, D. P. Rotella, & S. E. Ward (Eds.), Comprehensive Medicinal Chemistry III (pp. 130-149). (Reference Module in Chemistry, Molecular Sciences and Chemical Engineering). Elsevier. https://doi.org/10.1016/B978-0-12-409547-2.12376-5