Genetics of Drug Response in Diabetes

Ewan R. Pearson, Jose C. Florez

    Research output: Contribution to journalArticlepeer-review


    Patients with diabetes differ in how their diabetes responds to treatment. Some individuals can have a marked glycaemic response; others have a poor response. Some have adverse drug reactions (e.g. hypoglycaemia with sulphonylureas, or diarrhoea with metformin), others do not. Diabetes is one of the few disease areas (outside of cancer therapy) where pharmacogenetics is impacting on our understanding of drug mechanism, and on direct clinical care. In this review, we address the complexities of studying drug response in diabetes, and highlight key recent advances both within monogenic diabetes and common type 2 diabetes.

    Original languageEnglish
    Pages (from-to)158-172
    Number of pages15
    JournalFrontiers in Diabetes
    Publication statusPublished - 2014

    ASJC Scopus subject areas

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism
    • Endocrinology


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